Research output: Contribution to journal › Article › peer-review
Study of glycemic variability in pregnant women with gestational diabetes: Correlation between maternal clinical and laboratory findings and fetal ultrasound parameters. / Zimina, Natalya D.; Mitselya, Elena V.; Samoilova, Yulia G. et al.
In: Voprosy Ginekologii, Akusherstva i Perinatologii, Vol. 24, No. 5, 3, 2025, p. 27-31.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Study of glycemic variability in pregnant women with gestational diabetes: Correlation between maternal clinical and laboratory findings and fetal ultrasound parameters
AU - Zimina, Natalya D.
AU - Mitselya, Elena V.
AU - Samoilova, Yulia G.
AU - Kudlay, Dmitry A.
AU - Fomina, Svetlana V.
N1 - Исследование вариабельности глюкозы у беременных с гестационным сахарным диабетом: корреляция клинико-лабораторных данных матери и ультразвуковых параметров плода / Н.Д. Зимина, Е.В. Мицеля, Ю.Г. Самойлова, Д.А. Кудлай, С.В. Фомина // Вопросы гинекологии, акушерства и перинатологии. – 2025. – Т. 24. - № 5. – С. 27-31. – DOI 10.20953/1726-1678-2025-5-27-31. – EDN NONMPV.
PY - 2025
Y1 - 2025
N2 - Objective. To determine the correlation between glycemic variability (GV) in pregnant women with gestational diabetes (GD) and fetal parameters to identify factors affecting perinatal outcomes. Patients and methods. The study included 50 patients with GD who were fitted with a FreeStyle Libre 2 continuous glucose monitoring sensor. Fetal ultrasound was performed at 30 weeks’ gestation or later. Results. A correlation was found between certain clinical and laboratory parameters in pregnant women with GD and serum GV: A negative correlation between total bilirubin and time in range (TIR) (%) (R = -0.386, p = 0.049) indicated a tendency for TIR to decrease with increasing bilirubin levels, and a decrease in mean glucose levels (mmol/L) was observed with increasing maternal height (R = -0.338, p = 0.044) and fetal femur length (R = -0.491, p = 0.009). Correlations between maternal height and estimated glycated hemoglobin levels (%) (R = -0.339, p = 0.042) and femur length (R = -0.503, p = 0.007) were also significant. Furthermore, there was a correlation between maternal height and the percentage of GV (R = -0.438, p = 0.0322) and cholesterol levels (R = -0.394, p = 0.046). High cholesterol and femur length correlated with an increase in cases where glucose levels were below the target range (R = -0.583, p = 0.001 and R = -0.606, p = 0.047, respectively). Conclusion. There are significant correlations between GV and certain maternal clinical and laboratory findings, as well as fetal ultrasound parameters.
AB - Objective. To determine the correlation between glycemic variability (GV) in pregnant women with gestational diabetes (GD) and fetal parameters to identify factors affecting perinatal outcomes. Patients and methods. The study included 50 patients with GD who were fitted with a FreeStyle Libre 2 continuous glucose monitoring sensor. Fetal ultrasound was performed at 30 weeks’ gestation or later. Results. A correlation was found between certain clinical and laboratory parameters in pregnant women with GD and serum GV: A negative correlation between total bilirubin and time in range (TIR) (%) (R = -0.386, p = 0.049) indicated a tendency for TIR to decrease with increasing bilirubin levels, and a decrease in mean glucose levels (mmol/L) was observed with increasing maternal height (R = -0.338, p = 0.044) and fetal femur length (R = -0.491, p = 0.009). Correlations between maternal height and estimated glycated hemoglobin levels (%) (R = -0.339, p = 0.042) and femur length (R = -0.503, p = 0.007) were also significant. Furthermore, there was a correlation between maternal height and the percentage of GV (R = -0.438, p = 0.0322) and cholesterol levels (R = -0.394, p = 0.046). High cholesterol and femur length correlated with an increase in cases where glucose levels were below the target range (R = -0.583, p = 0.001 and R = -0.606, p = 0.047, respectively). Conclusion. There are significant correlations between GV and certain maternal clinical and laboratory findings, as well as fetal ultrasound parameters.
KW - Diabetic fetopathy
KW - Gestational diabetes
KW - Glycemic variability
KW - Perinatal outcomes
KW - Pregnancy risks
KW - Ultrasound diagnosis
KW - УЛЬТРАЗВУКОВАЯ ДИАГНОСТИКА
KW - ДИАБЕТИЧЕСКАЯ ФЕТОПАТИЯ
KW - ВАРИАБЕЛЬНОСТЬ ГЛЮКОЗЫ
KW - ГЕСТАЦИОННЫЙ САХАРНЫЙ ДИАБЕТ
KW - РИСКИ БЕРЕМЕННОСТИ
KW - ПЕРИНАТАЛЬНЫЕ ИСХОДЫ
UR - https://www.scopus.com/pages/publications/105026929703
UR - https://www.elibrary.ru/item.asp?id=84778948
UR - https://www.mendeley.com/catalogue/db75557d-b791-30f6-9d27-c0b48dad5230/
U2 - 10.20953/1726-1678-2025-5-27-31
DO - 10.20953/1726-1678-2025-5-27-31
M3 - Article
VL - 24
SP - 27
EP - 31
JO - Voprosy Ginekologii, Akusherstva i Perinatologii
JF - Voprosy Ginekologii, Akusherstva i Perinatologii
SN - 1726-1678
IS - 5
M1 - 3
ER -
ID: 74323976