Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Structure of an Ice-Binding Protein from Myoxocephalus octodecemspinosus Determined by Molecular Dynamics and Based on Circular Dichroism Spectra. / Oleinik, G. A.; Zhdanova, P.; Koval, V. V. и др.
в: Biophysics (Russian Federation), Том 68, № 4, 2, 08.2023, стр. 513-518.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Structure of an Ice-Binding Protein from Myoxocephalus octodecemspinosus Determined by Molecular Dynamics and Based on Circular Dichroism Spectra
AU - Oleinik, G. A.
AU - Zhdanova, P.
AU - Koval, V. V.
AU - Chernonosov, A. A.
AU - Baranova, S. V.
N1 - The research was carried out with the financial support of the Russian Science Foundation, project no. 23-24-00256. Публикация для корректировки.
PY - 2023/8
Y1 - 2023/8
N2 - The production of proteins capable of binding ice is one of the strategies evolved in biological organisms for survival in cold ecosystems where there is a risk of freezing. These proteins have an important ability to bind to the surface of ice, influence its growth and prevent cell damage and death. To understand the nature of interaction of such proteins with ice, it is necessary to know their structure. This study contributes to the understanding of the structural and dynamic mechanisms of action of ice-binding proteins that ensure the adaptation of organisms in critical conditions. The study of the contribution of proteins capable of binding ice to adaptation to cold conditions opens up wide opportunities in solving a number of important medical problems, including the development of effective cellular and organ cryoprotectants, as well as long-term storage of food products without loss of their consumer properties in the food industry.
AB - The production of proteins capable of binding ice is one of the strategies evolved in biological organisms for survival in cold ecosystems where there is a risk of freezing. These proteins have an important ability to bind to the surface of ice, influence its growth and prevent cell damage and death. To understand the nature of interaction of such proteins with ice, it is necessary to know their structure. This study contributes to the understanding of the structural and dynamic mechanisms of action of ice-binding proteins that ensure the adaptation of organisms in critical conditions. The study of the contribution of proteins capable of binding ice to adaptation to cold conditions opens up wide opportunities in solving a number of important medical problems, including the development of effective cellular and organ cryoprotectants, as well as long-term storage of food products without loss of their consumer properties in the food industry.
KW - antifreeze proteins
KW - circular dichroism
KW - cryoprotectants
KW - ice-binding proteins
KW - molecular dynamics
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85179975471&origin=inward&txGid=c5e7614cac37bd49e5fff799a94207e4
UR - https://www.mendeley.com/catalogue/5f89641d-c4ae-3312-9d50-9025dadf95ba/
U2 - 10.1134/S0006350923040152
DO - 10.1134/S0006350923040152
M3 - Article
VL - 68
SP - 513
EP - 518
JO - Biophysics (Russian Federation)
JF - Biophysics (Russian Federation)
SN - 0006-3509
IS - 4
M1 - 2
ER -
ID: 59554617