Structure of an Ice-Binding Protein from Myoxocephalus octodecemspinosus Determined by Molecular Dynamics and Based on Circular Dichroism Spectra

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Structure of an Ice-Binding Protein from Myoxocephalus octodecemspinosus Determined by Molecular Dynamics and Based on Circular Dichroism Spectra. / Oleinik, G. A.; Zhdanova, P.; Koval, V. V. et al.

In: Biophysics (Russian Federation), Vol. 68, No. 4, 2, 08.2023, p. 513-518.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{18a8ffde5cca45a0821a43378c8893e6,

title = "Structure of an Ice-Binding Protein from Myoxocephalus octodecemspinosus Determined by Molecular Dynamics and Based on Circular Dichroism Spectra",

abstract = "The production of proteins capable of binding ice is one of the strategies evolved in biological organisms for survival in cold ecosystems where there is a risk of freezing. These proteins have an important ability to bind to the surface of ice, influence its growth and prevent cell damage and death. To understand the nature of interaction of such proteins with ice, it is necessary to know their structure. This study contributes to the understanding of the structural and dynamic mechanisms of action of ice-binding proteins that ensure the adaptation of organisms in critical conditions. The study of the contribution of proteins capable of binding ice to adaptation to cold conditions opens up wide opportunities in solving a number of important medical problems, including the development of effective cellular and organ cryoprotectants, as well as long-term storage of food products without loss of their consumer properties in the food industry.",

keywords = "antifreeze proteins, circular dichroism, cryoprotectants, ice-binding proteins, molecular dynamics",

author = "Oleinik, {G. A.} and P. Zhdanova and Koval, {V. V.} and Chernonosov, {A. A.} and Baranova, {S. V.}",

note = "The research was carried out with the financial support of the Russian Science Foundation, project no. 23-24-00256. Публикация для корректировки.",

year = "2023",

month = aug,

doi = "10.1134/S0006350923040152",

language = "English",

volume = "68",

pages = "513--518",

journal = "Biophysics (Russian Federation)",

issn = "0006-3509",

publisher = "Maik Nauka-Interperiodica Publishing",

number = "4",

}

RIS

TY - JOUR

T1 - Structure of an Ice-Binding Protein from Myoxocephalus octodecemspinosus Determined by Molecular Dynamics and Based on Circular Dichroism Spectra

AU - Oleinik, G. A.

AU - Zhdanova, P.

AU - Koval, V. V.

AU - Chernonosov, A. A.

AU - Baranova, S. V.

N1 - The research was carried out with the financial support of the Russian Science Foundation, project no. 23-24-00256. Публикация для корректировки.

PY - 2023/8

Y1 - 2023/8

N2 - The production of proteins capable of binding ice is one of the strategies evolved in biological organisms for survival in cold ecosystems where there is a risk of freezing. These proteins have an important ability to bind to the surface of ice, influence its growth and prevent cell damage and death. To understand the nature of interaction of such proteins with ice, it is necessary to know their structure. This study contributes to the understanding of the structural and dynamic mechanisms of action of ice-binding proteins that ensure the adaptation of organisms in critical conditions. The study of the contribution of proteins capable of binding ice to adaptation to cold conditions opens up wide opportunities in solving a number of important medical problems, including the development of effective cellular and organ cryoprotectants, as well as long-term storage of food products without loss of their consumer properties in the food industry.

AB - The production of proteins capable of binding ice is one of the strategies evolved in biological organisms for survival in cold ecosystems where there is a risk of freezing. These proteins have an important ability to bind to the surface of ice, influence its growth and prevent cell damage and death. To understand the nature of interaction of such proteins with ice, it is necessary to know their structure. This study contributes to the understanding of the structural and dynamic mechanisms of action of ice-binding proteins that ensure the adaptation of organisms in critical conditions. The study of the contribution of proteins capable of binding ice to adaptation to cold conditions opens up wide opportunities in solving a number of important medical problems, including the development of effective cellular and organ cryoprotectants, as well as long-term storage of food products without loss of their consumer properties in the food industry.

KW - antifreeze proteins

KW - circular dichroism

KW - cryoprotectants

KW - ice-binding proteins

KW - molecular dynamics

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85179975471&origin=inward&txGid=c5e7614cac37bd49e5fff799a94207e4

UR - https://www.mendeley.com/catalogue/5f89641d-c4ae-3312-9d50-9025dadf95ba/

U2 - 10.1134/S0006350923040152

DO - 10.1134/S0006350923040152

M3 - Article

VL - 68

SP - 513

EP - 518

JO - Biophysics (Russian Federation)

JF - Biophysics (Russian Federation)

SN - 0006-3509

IS - 4

M1 - 2

ER -

ID: 59554617