Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Stabilization of TiO2 sols dispersity at physiological conditions and decrease their cytotoxic properties. / Shikina, Nadezhda V.; Bessudnova, Elena V.; Ryabchikova, Elena I. и др.
в: Journal of Nanoscience and Nanotechnology, Том 17, № 12, 12.2017, стр. 9312-9321.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Stabilization of TiO2 sols dispersity at physiological conditions and decrease their cytotoxic properties
AU - Shikina, Nadezhda V.
AU - Bessudnova, Elena V.
AU - Ryabchikova, Elena I.
AU - Levina, Asya S.
AU - Zarytova, Valentina F.
AU - Ismagilov, Zinfer R.
PY - 2017/12
Y1 - 2017/12
N2 - The effect of chemical nature of LiOH, NaOH, KOH and NH4OH electrolytes, surface modification of TiO2 particles with isopropyl glycidyl ether (IGE), mixing order of reactants, and dialysis conditions on the dispersion and cell damage of TiO2 sols at neutral pH has been studied. Investigation of TiO2 sols by a set of physicochemical methods (XRD, Raman spectroscopy, SAXS, AFM, TEM, and ζ-potential measurements) showed the highest dispersity of sols was reached by their neutralization with LiOH. Trypan blue staining and transmission electron microscopy of ultrathin cell sections were used to study in vitro the damaging effect in MDCK cell culture after its incubation with titanium dioxide nanoparticles. It was shown that the surface modification of TiO2 nanoparticles with IGE and phosphate groups diminished its toxic effect on the cells and prevented undesirable interaction of TiO2 with cell components.
AB - The effect of chemical nature of LiOH, NaOH, KOH and NH4OH electrolytes, surface modification of TiO2 particles with isopropyl glycidyl ether (IGE), mixing order of reactants, and dialysis conditions on the dispersion and cell damage of TiO2 sols at neutral pH has been studied. Investigation of TiO2 sols by a set of physicochemical methods (XRD, Raman spectroscopy, SAXS, AFM, TEM, and ζ-potential measurements) showed the highest dispersity of sols was reached by their neutralization with LiOH. Trypan blue staining and transmission electron microscopy of ultrathin cell sections were used to study in vitro the damaging effect in MDCK cell culture after its incubation with titanium dioxide nanoparticles. It was shown that the surface modification of TiO2 nanoparticles with IGE and phosphate groups diminished its toxic effect on the cells and prevented undesirable interaction of TiO2 with cell components.
KW - Aggregation
KW - Anatase
KW - Damaging effect
KW - MDCK cell
KW - Nanoparticles
KW - Titanium dioxide
KW - PARTICLES
KW - MDCK Cell
KW - Damaging Effect
KW - NANOMATERIALS
KW - TOXICITY
KW - NANOCOMPOSITES
KW - Titanium Dioxide
KW - CELL-CULTURE
KW - MICE
KW - TITANIUM-DIOXIDE NANOPARTICLES
UR - http://www.scopus.com/inward/record.url?scp=85030462486&partnerID=8YFLogxK
U2 - 10.1166/jnn.2017.13916
DO - 10.1166/jnn.2017.13916
M3 - Article
AN - SCOPUS:85030462486
VL - 17
SP - 9312
EP - 9321
JO - Journal of Nanoscience and Nanotechnology
JF - Journal of Nanoscience and Nanotechnology
SN - 1533-4880
IS - 12
ER -
ID: 8673342