Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Singlet Oxygen Production and Biological Activity of Hexanuclear Chalcocyanide Rhenium Cluster Complexes [{Re6Q8}(CN)6]4- (Q = S, Se, Te). / Solovieva, Anastasiya O.; Kirakci, Kaplan; Ivanov, Anton A. и др.
в: Inorganic Chemistry, Том 56, № 21, 06.11.2017, стр. 13491-13499.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Singlet Oxygen Production and Biological Activity of Hexanuclear Chalcocyanide Rhenium Cluster Complexes [{Re6Q8}(CN)6]4- (Q = S, Se, Te)
AU - Solovieva, Anastasiya O.
AU - Kirakci, Kaplan
AU - Ivanov, Anton A.
AU - Kubát, Pavel
AU - Pozmogova, Tatiana N.
AU - Miroshnichenko, Svetlana M.
AU - Vorontsova, Elena V.
AU - Chechushkov, Anton V.
AU - Trifonova, Kristina E.
AU - Fufaeva, Maria S.
AU - Kretov, Evgeniy I.
AU - Mironov, Yuri V.
AU - Poveshchenko, Alexander F.
AU - Lang, Kamil
AU - Shestopalov, Michael A.
PY - 2017/11/6
Y1 - 2017/11/6
N2 - Octahedral rhenium cluster complexes have recently emerged as relevant building blocks for the design of singlet oxygen photosensitizing materials toward biological applications such as blue-light photodynamic therapy. However, their singlet oxygen generation ability as well as biological properties have been studied only superficially. Herein we investigate in detail the singlet oxygen photogeneration, dark and photoinduced cytotoxicity, cellular uptake kinetics, cellular localization and in vitro photoinduced oxidative stress, and photodynamic cytotoxicity of the series of octahedral rhenium cluster complexes [{Re6Q8}(CN)6]4-, where Q = S, Se, Te. Our results demonstrate that the selenium-containing complex possesses optimal properties in terms of absorption and singlet oxygen productivity. These features coupled with the cellular internalization and low dark toxicity lead to the first photoinduced cytotoxic effect observed for a molecular [{M6Q8}L6] complex, making it a promising object for further study in terms of blue-light PDT.
AB - Octahedral rhenium cluster complexes have recently emerged as relevant building blocks for the design of singlet oxygen photosensitizing materials toward biological applications such as blue-light photodynamic therapy. However, their singlet oxygen generation ability as well as biological properties have been studied only superficially. Herein we investigate in detail the singlet oxygen photogeneration, dark and photoinduced cytotoxicity, cellular uptake kinetics, cellular localization and in vitro photoinduced oxidative stress, and photodynamic cytotoxicity of the series of octahedral rhenium cluster complexes [{Re6Q8}(CN)6]4-, where Q = S, Se, Te. Our results demonstrate that the selenium-containing complex possesses optimal properties in terms of absorption and singlet oxygen productivity. These features coupled with the cellular internalization and low dark toxicity lead to the first photoinduced cytotoxic effect observed for a molecular [{M6Q8}L6] complex, making it a promising object for further study in terms of blue-light PDT.
KW - PHOTOPHYSICAL PROPERTIES
KW - MOLECULAR-OXYGEN
KW - IODIDE CLUSTER
KW - LUMINESCENCE
KW - CYTOTOXICITY
KW - LIGANDS
KW - POLYMER
KW - SERIES
KW - STATE
KW - BR
UR - http://www.scopus.com/inward/record.url?scp=85033408326&partnerID=8YFLogxK
U2 - 10.1021/acs.inorgchem.7b02212
DO - 10.1021/acs.inorgchem.7b02212
M3 - Article
C2 - 28990789
AN - SCOPUS:85033408326
VL - 56
SP - 13491
EP - 13499
JO - Inorganic Chemistry
JF - Inorganic Chemistry
SN - 0020-1669
IS - 21
ER -
ID: 9699444