Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Simple and biodegradable mesoporous silica nanocarriers for enhancing antitumor therapy through photochemical synergism. / Yang, Yiping; Qin, Yuchang; Yang, Shengchao и др.
в: Journal of biomaterials applications, Том 38, № 4, 10.2023, стр. 538-547.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Simple and biodegradable mesoporous silica nanocarriers for enhancing antitumor therapy through photochemical synergism
AU - Yang, Yiping
AU - Qin, Yuchang
AU - Yang, Shengchao
AU - Liu, Tianyu
AU - Benassi, Enrico
AU - Cui, Lin
AU - Liu, Zhiyong
AU - Guo, Xuhong
AU - Li, Yongsheng
N1 - The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the International Cooperation Project (FZ001401) from CSC and the Major Project of the City Shihezi (2022ZD01).
PY - 2023/10
Y1 - 2023/10
N2 - The biosafety and degradability of nanocarriers have always been an important factor restricting their entry into the clinic. In this work, a new nano-system was prepared by coating the photothermal effect of dopamine-doped mesoporous silica nanoparticles with carboxymethyl chitin through electrostatic interaction, and is further anchored with folic acid on the surface for targeted delivery of anti-cancer the drug doxorubicin (DOX). The nano-system (DOX@PDA/MSN-CMCS-FA) is simply modified CMCS after being loaded with DOX and has good dispersibility, and the drug loading is 10.6%. In vitro release studies have shown that the release rate of PDA/MSN-CMCS-FA is 40% in pH 5.5. Effective degradation is debris in 14 d acidic environments. Due to the anti-infrared photothermal effects of PDA doping and DOX chemotherapy, the semi-lethal concentration (IC50) of nanoparticles (NPS) was 14.95 μg/mL, which can inhibit tumor cell growth by photochemical synergistic treatment, and have certain degradation performance.
AB - The biosafety and degradability of nanocarriers have always been an important factor restricting their entry into the clinic. In this work, a new nano-system was prepared by coating the photothermal effect of dopamine-doped mesoporous silica nanoparticles with carboxymethyl chitin through electrostatic interaction, and is further anchored with folic acid on the surface for targeted delivery of anti-cancer the drug doxorubicin (DOX). The nano-system (DOX@PDA/MSN-CMCS-FA) is simply modified CMCS after being loaded with DOX and has good dispersibility, and the drug loading is 10.6%. In vitro release studies have shown that the release rate of PDA/MSN-CMCS-FA is 40% in pH 5.5. Effective degradation is debris in 14 d acidic environments. Due to the anti-infrared photothermal effects of PDA doping and DOX chemotherapy, the semi-lethal concentration (IC50) of nanoparticles (NPS) was 14.95 μg/mL, which can inhibit tumor cell growth by photochemical synergistic treatment, and have certain degradation performance.
KW - pH-responsive
KW - dopamine
KW - mesoporous silica
KW - folic acid
KW - target
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85177074204&origin=inward&txGid=cb636f29d969d1f388512937ccf5d41d
U2 - 10.1177/08853282231200711
DO - 10.1177/08853282231200711
M3 - Article
C2 - 37957029
VL - 38
SP - 538
EP - 547
JO - Journal of biomaterials applications
JF - Journal of biomaterials applications
SN - 0885-3282
IS - 4
ER -
ID: 58297084