Standard

Simple and biodegradable mesoporous silica nanocarriers for enhancing antitumor therapy through photochemical synergism. / Yang, Yiping; Qin, Yuchang; Yang, Shengchao et al.

In: Journal of biomaterials applications, Vol. 38, No. 4, 10.2023, p. 538-547.

Research output: Contribution to journal › Article › peer-review

Harvard

Yang, Y, Qin, Y, Yang, S, Liu, T, Benassi, E, Cui, L, Liu, Z, Guo, X & Li, Y 2023, 'Simple and biodegradable mesoporous silica nanocarriers for enhancing antitumor therapy through photochemical synergism', Journal of biomaterials applications, vol. 38, no. 4, pp. 538-547. https://doi.org/10.1177/08853282231200711

APA

Yang, Y., Qin, Y., Yang, S., Liu, T., Benassi, E., Cui, L., Liu, Z., Guo, X., & Li, Y. (2023). Simple and biodegradable mesoporous silica nanocarriers for enhancing antitumor therapy through photochemical synergism. Journal of biomaterials applications, 38(4), 538-547. https://doi.org/10.1177/08853282231200711

Vancouver

Yang Y, Qin Y, Yang S, Liu T, Benassi E, Cui L et al. Simple and biodegradable mesoporous silica nanocarriers for enhancing antitumor therapy through photochemical synergism. Journal of biomaterials applications. 2023 Oct;38(4):538-547. doi: 10.1177/08853282231200711

Author

Yang, Yiping ; Qin, Yuchang ; Yang, Shengchao et al. / Simple and biodegradable mesoporous silica nanocarriers for enhancing antitumor therapy through photochemical synergism. In: Journal of biomaterials applications. 2023 ; Vol. 38, No. 4. pp. 538-547.

BibTeX

@article{6b6df535fe1742c1a325fac7be0d79db,
title = "Simple and biodegradable mesoporous silica nanocarriers for enhancing antitumor therapy through photochemical synergism",
abstract = "The biosafety and degradability of nanocarriers have always been an important factor restricting their entry into the clinic. In this work, a new nano-system was prepared by coating the photothermal effect of dopamine-doped mesoporous silica nanoparticles with carboxymethyl chitin through electrostatic interaction, and is further anchored with folic acid on the surface for targeted delivery of anti-cancer the drug doxorubicin (DOX). The nano-system (DOX@PDA/MSN-CMCS-FA) is simply modified CMCS after being loaded with DOX and has good dispersibility, and the drug loading is 10.6%. In vitro release studies have shown that the release rate of PDA/MSN-CMCS-FA is 40% in pH 5.5. Effective degradation is debris in 14 d acidic environments. Due to the anti-infrared photothermal effects of PDA doping and DOX chemotherapy, the semi-lethal concentration (IC50) of nanoparticles (NPS) was 14.95 μg/mL, which can inhibit tumor cell growth by photochemical synergistic treatment, and have certain degradation performance.",
keywords = "pH-responsive, dopamine, mesoporous silica, folic acid, target",
author = "Yiping Yang and Yuchang Qin and Shengchao Yang and Tianyu Liu and Enrico Benassi and Lin Cui and Zhiyong Liu and Xuhong Guo and Yongsheng Li",
note = "The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the International Cooperation Project (FZ001401) from CSC and the Major Project of the City Shihezi (2022ZD01).",
year = "2023",
month = oct,
doi = "10.1177/08853282231200711",
language = "English",
volume = "38",
pages = "538--547",
journal = "Journal of biomaterials applications",
issn = "0885-3282",
publisher = "SAGE Publications Ltd",
number = "4",

}

RIS

TY - JOUR

T1 - Simple and biodegradable mesoporous silica nanocarriers for enhancing antitumor therapy through photochemical synergism

AU - Yang, Yiping

AU - Qin, Yuchang

AU - Yang, Shengchao

AU - Liu, Tianyu

AU - Benassi, Enrico

AU - Cui, Lin

AU - Liu, Zhiyong

AU - Guo, Xuhong

AU - Li, Yongsheng

N1 - The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the International Cooperation Project (FZ001401) from CSC and the Major Project of the City Shihezi (2022ZD01).

PY - 2023/10

Y1 - 2023/10

N2 - The biosafety and degradability of nanocarriers have always been an important factor restricting their entry into the clinic. In this work, a new nano-system was prepared by coating the photothermal effect of dopamine-doped mesoporous silica nanoparticles with carboxymethyl chitin through electrostatic interaction, and is further anchored with folic acid on the surface for targeted delivery of anti-cancer the drug doxorubicin (DOX). The nano-system (DOX@PDA/MSN-CMCS-FA) is simply modified CMCS after being loaded with DOX and has good dispersibility, and the drug loading is 10.6%. In vitro release studies have shown that the release rate of PDA/MSN-CMCS-FA is 40% in pH 5.5. Effective degradation is debris in 14 d acidic environments. Due to the anti-infrared photothermal effects of PDA doping and DOX chemotherapy, the semi-lethal concentration (IC50) of nanoparticles (NPS) was 14.95 μg/mL, which can inhibit tumor cell growth by photochemical synergistic treatment, and have certain degradation performance.

AB - The biosafety and degradability of nanocarriers have always been an important factor restricting their entry into the clinic. In this work, a new nano-system was prepared by coating the photothermal effect of dopamine-doped mesoporous silica nanoparticles with carboxymethyl chitin through electrostatic interaction, and is further anchored with folic acid on the surface for targeted delivery of anti-cancer the drug doxorubicin (DOX). The nano-system (DOX@PDA/MSN-CMCS-FA) is simply modified CMCS after being loaded with DOX and has good dispersibility, and the drug loading is 10.6%. In vitro release studies have shown that the release rate of PDA/MSN-CMCS-FA is 40% in pH 5.5. Effective degradation is debris in 14 d acidic environments. Due to the anti-infrared photothermal effects of PDA doping and DOX chemotherapy, the semi-lethal concentration (IC50) of nanoparticles (NPS) was 14.95 μg/mL, which can inhibit tumor cell growth by photochemical synergistic treatment, and have certain degradation performance.

KW - pH-responsive

KW - dopamine

KW - mesoporous silica

KW - folic acid

KW - target

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85177074204&origin=inward&txGid=cb636f29d969d1f388512937ccf5d41d

U2 - 10.1177/08853282231200711

DO - 10.1177/08853282231200711

M3 - Article

C2 - 37957029

VL - 38

SP - 538

EP - 547

JO - Journal of biomaterials applications

JF - Journal of biomaterials applications

SN - 0885-3282

IS - 4

ER -

ID: 58297084