TY - JOUR

T1 - Sex and strain differences BETWEEN DISC1-L100P AND C57BL/6 MICE IN PASSIVE AVOIDANCE CONDITIONING DEFINATION

AU - Chizhova, N. D.

AU - Smirnova, K. V.

AU - Dubrovina, N. I.

AU - Lipina, T. V.

AU - Amstislavskaya, T. G.

N1 - Половые и линейные различия у мышей DISC1-L100P и C57BL/6 В угашении условной реакции пассивного избегания / Н. Д. Чижова, К. В. Смирнова, Н. И. Дубровина [и др.] // Журнал высшей нервной деятельности им. И.П. Павлова. – 2023. – Т. 73. - № 3. – С. 425-432. Публикация для корректировки.

PY - 2023

Y1 - 2023

N2 - Sex and strain differences in the passive avoidance learning and extinction in male and female of DISC1-L100P mice and wild-type control mice were investigated. It was shown that male and female mice of both strains were well trained in the conditioned response of passive avoidance, but differed in fear memory extinction, the ability to form a new memory trace about the safety of the previously punished dark compartment of apparatus in the procedure of repeated testing. There was a deficit of fear memory extinction in females of DISC1-L100P and C57BL/6 mice compared to males. At the same time, interstrain differences in the dynamics of passive avoidance extinction in female mice of these strains were revealed. Results also showed that DISC1-L100P males differed from C57BL/6 in terms of the time to achieve complete extinction of this reaction.

AB - Sex and strain differences in the passive avoidance learning and extinction in male and female of DISC1-L100P mice and wild-type control mice were investigated. It was shown that male and female mice of both strains were well trained in the conditioned response of passive avoidance, but differed in fear memory extinction, the ability to form a new memory trace about the safety of the previously punished dark compartment of apparatus in the procedure of repeated testing. There was a deficit of fear memory extinction in females of DISC1-L100P and C57BL/6 mice compared to males. At the same time, interstrain differences in the dynamics of passive avoidance extinction in female mice of these strains were revealed. Results also showed that DISC1-L100P males differed from C57BL/6 in terms of the time to achieve complete extinction of this reaction.

KW - C57BL/6

KW - DISC1-L100P

KW - extinction

KW - fear

KW - mice

KW - passive avoidance

KW - schizophrenia

KW - sex differences

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85177199988&origin=inward&txGid=6e684fc9c0f581087e110fa55842b5a2

UR - https://www.elibrary.ru/item.asp?id=53738598

UR - https://www.mendeley.com/catalogue/e9bf8451-a4bd-3b78-9c81-4642e7724c89/

U2 - 10.31857/S004446772303005X

DO - 10.31857/S004446772303005X

M3 - Article

VL - 73

SP - 425

EP - 432

JO - Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova

JF - Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova

SN - 0044-4677

IS - 3

ER -