Research output: Contribution to journal › Article › peer-review
Sex and strain differences BETWEEN DISC1-L100P AND C57BL/6 MICE IN PASSIVE AVOIDANCE CONDITIONING DEFINATION. / Chizhova, N. D.; Smirnova, K. V.; Dubrovina, N. I. et al.
In: Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova, Vol. 73, No. 3, 2023, p. 425-432.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Sex and strain differences BETWEEN DISC1-L100P AND C57BL/6 MICE IN PASSIVE AVOIDANCE CONDITIONING DEFINATION
AU - Chizhova, N. D.
AU - Smirnova, K. V.
AU - Dubrovina, N. I.
AU - Lipina, T. V.
AU - Amstislavskaya, T. G.
N1 - Половые и линейные различия у мышей DISC1-L100P и C57BL/6 В угашении условной реакции пассивного избегания / Н. Д. Чижова, К. В. Смирнова, Н. И. Дубровина [и др.] // Журнал высшей нервной деятельности им. И.П. Павлова. – 2023. – Т. 73. - № 3. – С. 425-432. Публикация для корректировки.
PY - 2023
Y1 - 2023
N2 - Sex and strain differences in the passive avoidance learning and extinction in male and female of DISC1-L100P mice and wild-type control mice were investigated. It was shown that male and female mice of both strains were well trained in the conditioned response of passive avoidance, but differed in fear memory extinction, the ability to form a new memory trace about the safety of the previously punished dark compartment of apparatus in the procedure of repeated testing. There was a deficit of fear memory extinction in females of DISC1-L100P and C57BL/6 mice compared to males. At the same time, interstrain differences in the dynamics of passive avoidance extinction in female mice of these strains were revealed. Results also showed that DISC1-L100P males differed from C57BL/6 in terms of the time to achieve complete extinction of this reaction.
AB - Sex and strain differences in the passive avoidance learning and extinction in male and female of DISC1-L100P mice and wild-type control mice were investigated. It was shown that male and female mice of both strains were well trained in the conditioned response of passive avoidance, but differed in fear memory extinction, the ability to form a new memory trace about the safety of the previously punished dark compartment of apparatus in the procedure of repeated testing. There was a deficit of fear memory extinction in females of DISC1-L100P and C57BL/6 mice compared to males. At the same time, interstrain differences in the dynamics of passive avoidance extinction in female mice of these strains were revealed. Results also showed that DISC1-L100P males differed from C57BL/6 in terms of the time to achieve complete extinction of this reaction.
KW - C57BL/6
KW - DISC1-L100P
KW - extinction
KW - fear
KW - mice
KW - passive avoidance
KW - schizophrenia
KW - sex differences
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85177199988&origin=inward&txGid=6e684fc9c0f581087e110fa55842b5a2
UR - https://www.elibrary.ru/item.asp?id=53738598
UR - https://www.mendeley.com/catalogue/e9bf8451-a4bd-3b78-9c81-4642e7724c89/
U2 - 10.31857/S004446772303005X
DO - 10.31857/S004446772303005X
M3 - Article
VL - 73
SP - 425
EP - 432
JO - Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova
JF - Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova
SN - 0044-4677
IS - 3
ER -
ID: 59234193