Результаты исследований: Научные публикации в периодических изданиях › статья по материалам конференции › Рецензирование
Screening and characterization of cocrystal formation between betulin and terephthalic acid. / Mikhailovskaya, Anastasiya V.; Myz, Svetlana A.; Bulina, Natalia V. и др.
в: Materials Today: Proceedings, Том 25, 2019, стр. 381-383.Результаты исследований: Научные публикации в периодических изданиях › статья по материалам конференции › Рецензирование
}
TY - JOUR
T1 - Screening and characterization of cocrystal formation between betulin and terephthalic acid
AU - Mikhailovskaya, Anastasiya V.
AU - Myz, Svetlana A.
AU - Bulina, Natalia V.
AU - Gerasimov, Konstantin B.
AU - Kuznetsova, Svetlana A.
AU - Shakhtshneider, Tatyana P.
N1 - Publisher Copyright: © 2019 Elsevier Ltd. Copyright: Copyright 2020 Elsevier B.V., All rights reserved
PY - 2019
Y1 - 2019
N2 - The pharmaceutical cocrystals are nowdays intensively studied due to the improvements of solubility, stability, processability, etc. of the drugs. In this work, the cocrystals of betulin with terephthalic acid as a coformer were prepared by liquid-assisted grinding method. The formation of cocrystals was confirmed by powder X-ray diffraction, IR spectroscopy and thermal analysis methods. HPLC analysis showed that in the case of betulin - terephthalic acid cocrystals, solubility of betulin was significantly improved compared to the initial betulin as well as betulin from cocrystals with aliphatic dicarboxylic acids which were earlier prepared.
AB - The pharmaceutical cocrystals are nowdays intensively studied due to the improvements of solubility, stability, processability, etc. of the drugs. In this work, the cocrystals of betulin with terephthalic acid as a coformer were prepared by liquid-assisted grinding method. The formation of cocrystals was confirmed by powder X-ray diffraction, IR spectroscopy and thermal analysis methods. HPLC analysis showed that in the case of betulin - terephthalic acid cocrystals, solubility of betulin was significantly improved compared to the initial betulin as well as betulin from cocrystals with aliphatic dicarboxylic acids which were earlier prepared.
KW - Betulin
KW - Co-grinding
KW - Cocrystal
KW - Solubility
KW - Terephthalic acid
UR - http://www.scopus.com/inward/record.url?scp=85086948314&partnerID=8YFLogxK
U2 - 10.1016/j.matpr.2019.12.096
DO - 10.1016/j.matpr.2019.12.096
M3 - Conference article
AN - SCOPUS:85086948314
VL - 25
SP - 381
EP - 383
JO - Materials Today: Proceedings
JF - Materials Today: Proceedings
SN - 2214-7853
T2 - 3rd All-Russian Conference, with International Participation Hot Topics of Solid State Chemistry : From New Ideas to New Materials, HTSSC 2019
Y2 - 1 October 2019 through 5 October 2019
ER -
ID: 26145269