TY - JOUR

T1 - SABRE Hyperpolarization of Bipyridine Stabilized Ir-Complex at High, Low and Ultralow Magnetic Fields

AU - Pravdivtsev, Andrey N.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - A strong limitation of nuclear magnetic resonance is its low inherent sensitivity that can be overcome by using an appropriate hyperpolarization technique. Presently, dynamic nuclear polarization and spin-exchange optical pumping are the only hyperpolarization techniques that are used in applied medicine. However, both are relatively complex in use and expensive. Here we present a modification of the signal amplification by reversible exchange (SABRE) hyperpolarization method-SABRE on stabilized Ir-complexes. A stabilized Ir-complex (here we used bipyridine for stabilization) can be hyperpolarized in a wide range of magnetic fields from a few μT upto 10 T with 15N polarization of about 1-3%. Moreover, the investigated complex can be incorporated into biomolecules or other bulky molecules; in this situation exchange with para-hydrogen will allow one to continuously generate hyperpolarization.

AB - A strong limitation of nuclear magnetic resonance is its low inherent sensitivity that can be overcome by using an appropriate hyperpolarization technique. Presently, dynamic nuclear polarization and spin-exchange optical pumping are the only hyperpolarization techniques that are used in applied medicine. However, both are relatively complex in use and expensive. Here we present a modification of the signal amplification by reversible exchange (SABRE) hyperpolarization method-SABRE on stabilized Ir-complexes. A stabilized Ir-complex (here we used bipyridine for stabilization) can be hyperpolarized in a wide range of magnetic fields from a few μT upto 10 T with 15N polarization of about 1-3%. Moreover, the investigated complex can be incorporated into biomolecules or other bulky molecules; in this situation exchange with para-hydrogen will allow one to continuously generate hyperpolarization.

KW - bipyridine

KW - NMR

KW - para-hydrogen

KW - SABRE

KW - PARA-HYDROGEN

KW - LEVEL ANTI-CROSSINGS

KW - RESONANCE

KW - SPIN HYPERPOLARIZATION

KW - PARAHYDROGEN

KW - POLARIZATION TRANSFER

KW - CATALYSTS

KW - SIGNAL AMPLIFICATION

UR - http://www.scopus.com/inward/record.url?scp=85012283678&partnerID=8YFLogxK

U2 - 10.1515/zpch-2016-0810

DO - 10.1515/zpch-2016-0810

M3 - Article

AN - SCOPUS:85012283678

VL - 231

SP - 497

EP - 511

JO - Zeitschrift fur Physikalische Chemie

JF - Zeitschrift fur Physikalische Chemie

SN - 0942-9352

IS - 3

ER -