Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Robertsonian fusion triggers recombination suppression on sex chromosomes in Coleonyx geckos. / Lisachov, Artem; Tishakova, Katerina; Romanenko, Svetlana и др.
в: Scientific Reports, Том 13, № 1, 15502, 19.09.2023.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Robertsonian fusion triggers recombination suppression on sex chromosomes in Coleonyx geckos
AU - Lisachov, Artem
AU - Tishakova, Katerina
AU - Romanenko, Svetlana
AU - Lisachova, Lada
AU - Davletshina, Guzel
AU - Prokopov, Dmitry
AU - Kratochvíl, Lukáš
AU - O Brien, Patricia
AU - Ferguson-Smith, Malcolm
AU - Borodin, Pavel
AU - Trifonov, Vladimir
N1 - The research was completed using equipment (materials) of the Core Facilities Centre “Cryobank of cell cultures” Institute of Molecular and Cellular Biology Siberian Branch of Russian Academy of Sciences (Novosibirsk, Russia). The research was funded by the Ministry of Science and Higher Education of the Russian Federation grant number FWNR-2022-0015 (for PB), research grant of the Russian Science Foundation 19-14-00034-P (for KT and SR) and Czech Science Foundation project number 20-27236J (for LK). © 2023. Springer Nature Limited.
PY - 2023/9/19
Y1 - 2023/9/19
N2 - The classical hypothesis proposes that the lack of recombination on sex chromosomes arises due to selection for linkage between a sex-determining locus and sexually antagonistic loci, primarily facilitated by inversions. However, cessation of recombination on sex chromosomes could be attributed also to neutral processes, connected with other chromosome rearrangements or can reflect sex-specific recombination patterns existing already before sex chromosome differentiation. Three Coleonyx gecko species share a complex X1X1X2X2/X1X2Y system of sex chromosomes evolved via a fusion of the Y chromosome with an autosome. We analyzed synaptonemal complexes and sequenced flow-sorted sex chromosomes to investigate the effect of chromosomal rearrangement on recombination and differentiation of these sex chromosomes. The gecko sex chromosomes evolved from syntenic regions that were also co-opted also for sex chromosomes in other reptiles. We showed that in male geckos, recombination is less prevalent in the proximal regions of chromosomes and is even further drastically reduced around the centromere of the neo-Y chromosome. We highlight that pre-existing recombination patterns and Robertsonian fusions can be responsible for the cessation of recombination on sex chromosomes and that such processes can be largely neutral.
AB - The classical hypothesis proposes that the lack of recombination on sex chromosomes arises due to selection for linkage between a sex-determining locus and sexually antagonistic loci, primarily facilitated by inversions. However, cessation of recombination on sex chromosomes could be attributed also to neutral processes, connected with other chromosome rearrangements or can reflect sex-specific recombination patterns existing already before sex chromosome differentiation. Three Coleonyx gecko species share a complex X1X1X2X2/X1X2Y system of sex chromosomes evolved via a fusion of the Y chromosome with an autosome. We analyzed synaptonemal complexes and sequenced flow-sorted sex chromosomes to investigate the effect of chromosomal rearrangement on recombination and differentiation of these sex chromosomes. The gecko sex chromosomes evolved from syntenic regions that were also co-opted also for sex chromosomes in other reptiles. We showed that in male geckos, recombination is less prevalent in the proximal regions of chromosomes and is even further drastically reduced around the centromere of the neo-Y chromosome. We highlight that pre-existing recombination patterns and Robertsonian fusions can be responsible for the cessation of recombination on sex chromosomes and that such processes can be largely neutral.
KW - Female
KW - Animals
KW - Male
KW - Lizards/genetics
KW - Sex Chromosomes/genetics
KW - Y Chromosome/genetics
KW - Cell Movement
KW - Recombination, Genetic
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85171671254&origin=inward&txGid=e8f5317a9a07214a043e457f4598ee52
U2 - 10.1038/s41598-023-39937-2
DO - 10.1038/s41598-023-39937-2
M3 - Article
C2 - 37726346
VL - 13
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 15502
ER -
ID: 55483874