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Robertsonian fusion triggers recombination suppression on sex chromosomes in Coleonyx geckos. / Lisachov, Artem; Tishakova, Katerina; Romanenko, Svetlana et al.

In: Scientific Reports, Vol. 13, No. 1, 15502, 19.09.2023.

Research output: Contribution to journal › Article › peer-review

Harvard

Lisachov, A, Tishakova, K, Romanenko, S, Lisachova, L, Davletshina, G, Prokopov, D, Kratochvíl, L, O Brien, P, Ferguson-Smith, M, Borodin, P & Trifonov, V 2023, 'Robertsonian fusion triggers recombination suppression on sex chromosomes in Coleonyx geckos', Scientific Reports, vol. 13, no. 1, 15502. https://doi.org/10.1038/s41598-023-39937-2

APA

Lisachov, A., Tishakova, K., Romanenko, S., Lisachova, L., Davletshina, G., Prokopov, D., Kratochvíl, L., O Brien, P., Ferguson-Smith, M., Borodin, P., & Trifonov, V. (2023). Robertsonian fusion triggers recombination suppression on sex chromosomes in Coleonyx geckos. Scientific Reports, 13(1), [15502]. https://doi.org/10.1038/s41598-023-39937-2

Vancouver

Lisachov A, Tishakova K, Romanenko S, Lisachova L, Davletshina G, Prokopov D et al. Robertsonian fusion triggers recombination suppression on sex chromosomes in Coleonyx geckos. Scientific Reports. 2023 Sept 19;13(1):15502. doi: 10.1038/s41598-023-39937-2

Author

Lisachov, Artem ; Tishakova, Katerina ; Romanenko, Svetlana et al. / Robertsonian fusion triggers recombination suppression on sex chromosomes in Coleonyx geckos. In: Scientific Reports. 2023 ; Vol. 13, No. 1.

BibTeX

@article{be25aa8669924edd9d1f0027d1fbc289,
title = "Robertsonian fusion triggers recombination suppression on sex chromosomes in Coleonyx geckos",
abstract = "The classical hypothesis proposes that the lack of recombination on sex chromosomes arises due to selection for linkage between a sex-determining locus and sexually antagonistic loci, primarily facilitated by inversions. However, cessation of recombination on sex chromosomes could be attributed also to neutral processes, connected with other chromosome rearrangements or can reflect sex-specific recombination patterns existing already before sex chromosome differentiation. Three Coleonyx gecko species share a complex X1X1X2X2/X1X2Y system of sex chromosomes evolved via a fusion of the Y chromosome with an autosome. We analyzed synaptonemal complexes and sequenced flow-sorted sex chromosomes to investigate the effect of chromosomal rearrangement on recombination and differentiation of these sex chromosomes. The gecko sex chromosomes evolved from syntenic regions that were also co-opted also for sex chromosomes in other reptiles. We showed that in male geckos, recombination is less prevalent in the proximal regions of chromosomes and is even further drastically reduced around the centromere of the neo-Y chromosome. We highlight that pre-existing recombination patterns and Robertsonian fusions can be responsible for the cessation of recombination on sex chromosomes and that such processes can be largely neutral.",
keywords = "Female, Animals, Male, Lizards/genetics, Sex Chromosomes/genetics, Y Chromosome/genetics, Cell Movement, Recombination, Genetic",
author = "Artem Lisachov and Katerina Tishakova and Svetlana Romanenko and Lada Lisachova and Guzel Davletshina and Dmitry Prokopov and Luk{\'a}{\v s} Kratochv{\'i}l and {O Brien}, Patricia and Malcolm Ferguson-Smith and Pavel Borodin and Vladimir Trifonov",
note = "The research was completed using equipment (materials) of the Core Facilities Centre “Cryobank of cell cultures” Institute of Molecular and Cellular Biology Siberian Branch of Russian Academy of Sciences (Novosibirsk, Russia). The research was funded by the Ministry of Science and Higher Education of the Russian Federation grant number FWNR-2022-0015 (for PB), research grant of the Russian Science Foundation 19-14-00034-P (for KT and SR) and Czech Science Foundation project number 20-27236J (for LK). {\textcopyright} 2023. Springer Nature Limited.",
year = "2023",
month = sep,
day = "19",
doi = "10.1038/s41598-023-39937-2",
language = "English",
volume = "13",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Robertsonian fusion triggers recombination suppression on sex chromosomes in Coleonyx geckos

AU - Lisachov, Artem

AU - Tishakova, Katerina

AU - Romanenko, Svetlana

AU - Lisachova, Lada

AU - Davletshina, Guzel

AU - Prokopov, Dmitry

AU - Kratochvíl, Lukáš

AU - O Brien, Patricia

AU - Ferguson-Smith, Malcolm

AU - Borodin, Pavel

AU - Trifonov, Vladimir

N1 - The research was completed using equipment (materials) of the Core Facilities Centre “Cryobank of cell cultures” Institute of Molecular and Cellular Biology Siberian Branch of Russian Academy of Sciences (Novosibirsk, Russia). The research was funded by the Ministry of Science and Higher Education of the Russian Federation grant number FWNR-2022-0015 (for PB), research grant of the Russian Science Foundation 19-14-00034-P (for KT and SR) and Czech Science Foundation project number 20-27236J (for LK). © 2023. Springer Nature Limited.

PY - 2023/9/19

Y1 - 2023/9/19

N2 - The classical hypothesis proposes that the lack of recombination on sex chromosomes arises due to selection for linkage between a sex-determining locus and sexually antagonistic loci, primarily facilitated by inversions. However, cessation of recombination on sex chromosomes could be attributed also to neutral processes, connected with other chromosome rearrangements or can reflect sex-specific recombination patterns existing already before sex chromosome differentiation. Three Coleonyx gecko species share a complex X1X1X2X2/X1X2Y system of sex chromosomes evolved via a fusion of the Y chromosome with an autosome. We analyzed synaptonemal complexes and sequenced flow-sorted sex chromosomes to investigate the effect of chromosomal rearrangement on recombination and differentiation of these sex chromosomes. The gecko sex chromosomes evolved from syntenic regions that were also co-opted also for sex chromosomes in other reptiles. We showed that in male geckos, recombination is less prevalent in the proximal regions of chromosomes and is even further drastically reduced around the centromere of the neo-Y chromosome. We highlight that pre-existing recombination patterns and Robertsonian fusions can be responsible for the cessation of recombination on sex chromosomes and that such processes can be largely neutral.

AB - The classical hypothesis proposes that the lack of recombination on sex chromosomes arises due to selection for linkage between a sex-determining locus and sexually antagonistic loci, primarily facilitated by inversions. However, cessation of recombination on sex chromosomes could be attributed also to neutral processes, connected with other chromosome rearrangements or can reflect sex-specific recombination patterns existing already before sex chromosome differentiation. Three Coleonyx gecko species share a complex X1X1X2X2/X1X2Y system of sex chromosomes evolved via a fusion of the Y chromosome with an autosome. We analyzed synaptonemal complexes and sequenced flow-sorted sex chromosomes to investigate the effect of chromosomal rearrangement on recombination and differentiation of these sex chromosomes. The gecko sex chromosomes evolved from syntenic regions that were also co-opted also for sex chromosomes in other reptiles. We showed that in male geckos, recombination is less prevalent in the proximal regions of chromosomes and is even further drastically reduced around the centromere of the neo-Y chromosome. We highlight that pre-existing recombination patterns and Robertsonian fusions can be responsible for the cessation of recombination on sex chromosomes and that such processes can be largely neutral.

KW - Female

KW - Animals

KW - Male

KW - Lizards/genetics

KW - Sex Chromosomes/genetics

KW - Y Chromosome/genetics

KW - Cell Movement

KW - Recombination, Genetic

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85171671254&origin=inward&txGid=e8f5317a9a07214a043e457f4598ee52

U2 - 10.1038/s41598-023-39937-2

DO - 10.1038/s41598-023-39937-2

M3 - Article

C2 - 37726346

VL - 13

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 15502

ER -

ID: 55483874