TY - JOUR

T1 - Radiation Effects on Brain Extracellular Matrix

AU - Grigorieva, Elvira V.

N1 - Copyright © 2020 Grigorieva.

PY - 2020/10/2

Y1 - 2020/10/2

N2 - Radiotherapy is an important therapeutic approach to treating malignant tumors of different localization, including brain cancer. Glioblastoma multiforme (GBM) represents the most aggressive brain tumor, which develops relapsed disease during the 1st year after the surgical removal of the primary node, in spite of active adjuvant radiochemotherapy. More and more evidence suggests that the treatment's success might be determined by the balance of expected antitumor effects of the treatment and its non-targeted side effects on the surrounding brain tissue. Radiation-induced damage of the GBM microenvironment might create tumor-susceptible niche facilitating proliferation and invasion of the residual glioma cells and the disease relapse. Understanding of molecular mechanisms of radiation-induced changes in brain ECM might help to reconsider and improve conventional anti-glioblastoma radiotherapy, taking into account the balance between its antitumor and ECM-destructing activities. Although little is currently known about the radiation-induced changes in brain ECM, this review summarizes current knowledge about irradiation effects onto the main components of brain ECM such as proteoglycans, glycosaminoglycans, glycoproteins, and the enzymes responsible for their modification and degradation.

AB - Radiotherapy is an important therapeutic approach to treating malignant tumors of different localization, including brain cancer. Glioblastoma multiforme (GBM) represents the most aggressive brain tumor, which develops relapsed disease during the 1st year after the surgical removal of the primary node, in spite of active adjuvant radiochemotherapy. More and more evidence suggests that the treatment's success might be determined by the balance of expected antitumor effects of the treatment and its non-targeted side effects on the surrounding brain tissue. Radiation-induced damage of the GBM microenvironment might create tumor-susceptible niche facilitating proliferation and invasion of the residual glioma cells and the disease relapse. Understanding of molecular mechanisms of radiation-induced changes in brain ECM might help to reconsider and improve conventional anti-glioblastoma radiotherapy, taking into account the balance between its antitumor and ECM-destructing activities. Although little is currently known about the radiation-induced changes in brain ECM, this review summarizes current knowledge about irradiation effects onto the main components of brain ECM such as proteoglycans, glycosaminoglycans, glycoproteins, and the enzymes responsible for their modification and degradation.

KW - brain irradiation

KW - chondroitin sulfate

KW - extracellular matrix

KW - glioblastoma radiotherapy

KW - heparan sulfate

KW - heparanase

KW - metalloproteinase

KW - proteoglycan expression

KW - SYSTEM

KW - CHONDROITIN SULFATE

KW - PROTEOGLYCANS

KW - MALIGNANT GLIOMA

KW - IRRADIATION

KW - INVASION

KW - HEPARAN-SULFATE

KW - RADIOTHERAPY

KW - OLIGODENDROCYTE PROGENITOR CELLS

KW - EXPRESSION

UR - http://www.scopus.com/inward/record.url?scp=85092918304&partnerID=8YFLogxK

U2 - 10.3389/fonc.2020.576701

DO - 10.3389/fonc.2020.576701

M3 - Review article

C2 - 33134175

AN - SCOPUS:85092918304

VL - 10

JO - Frontiers in Oncology

JF - Frontiers in Oncology

SN - 2234-943X

M1 - 576701

ER -