Radiation Effects on Brain Extracellular Matrix. / Grigorieva, Elvira V.
In: Frontiers in Oncology, Vol. 10, 576701, 02.10.2020.Research output: Contribution to journal › Review article › peer-review
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TY - JOUR
T1 - Radiation Effects on Brain Extracellular Matrix
AU - Grigorieva, Elvira V.
N1 - Copyright © 2020 Grigorieva.
PY - 2020/10/2
Y1 - 2020/10/2
N2 - Radiotherapy is an important therapeutic approach to treating malignant tumors of different localization, including brain cancer. Glioblastoma multiforme (GBM) represents the most aggressive brain tumor, which develops relapsed disease during the 1st year after the surgical removal of the primary node, in spite of active adjuvant radiochemotherapy. More and more evidence suggests that the treatment's success might be determined by the balance of expected antitumor effects of the treatment and its non-targeted side effects on the surrounding brain tissue. Radiation-induced damage of the GBM microenvironment might create tumor-susceptible niche facilitating proliferation and invasion of the residual glioma cells and the disease relapse. Understanding of molecular mechanisms of radiation-induced changes in brain ECM might help to reconsider and improve conventional anti-glioblastoma radiotherapy, taking into account the balance between its antitumor and ECM-destructing activities. Although little is currently known about the radiation-induced changes in brain ECM, this review summarizes current knowledge about irradiation effects onto the main components of brain ECM such as proteoglycans, glycosaminoglycans, glycoproteins, and the enzymes responsible for their modification and degradation.
AB - Radiotherapy is an important therapeutic approach to treating malignant tumors of different localization, including brain cancer. Glioblastoma multiforme (GBM) represents the most aggressive brain tumor, which develops relapsed disease during the 1st year after the surgical removal of the primary node, in spite of active adjuvant radiochemotherapy. More and more evidence suggests that the treatment's success might be determined by the balance of expected antitumor effects of the treatment and its non-targeted side effects on the surrounding brain tissue. Radiation-induced damage of the GBM microenvironment might create tumor-susceptible niche facilitating proliferation and invasion of the residual glioma cells and the disease relapse. Understanding of molecular mechanisms of radiation-induced changes in brain ECM might help to reconsider and improve conventional anti-glioblastoma radiotherapy, taking into account the balance between its antitumor and ECM-destructing activities. Although little is currently known about the radiation-induced changes in brain ECM, this review summarizes current knowledge about irradiation effects onto the main components of brain ECM such as proteoglycans, glycosaminoglycans, glycoproteins, and the enzymes responsible for their modification and degradation.
KW - brain irradiation
KW - chondroitin sulfate
KW - extracellular matrix
KW - glioblastoma radiotherapy
KW - heparan sulfate
KW - heparanase
KW - metalloproteinase
KW - proteoglycan expression
KW - SYSTEM
KW - CHONDROITIN SULFATE
KW - PROTEOGLYCANS
KW - MALIGNANT GLIOMA
KW - IRRADIATION
KW - INVASION
KW - HEPARAN-SULFATE
KW - RADIOTHERAPY
KW - OLIGODENDROCYTE PROGENITOR CELLS
KW - EXPRESSION
UR - http://www.scopus.com/inward/record.url?scp=85092918304&partnerID=8YFLogxK
U2 - 10.3389/fonc.2020.576701
DO - 10.3389/fonc.2020.576701
M3 - Review article
C2 - 33134175
AN - SCOPUS:85092918304
VL - 10
JO - Frontiers in Oncology
JF - Frontiers in Oncology
SN - 2234-943X
M1 - 576701
ER -
ID: 25687526