TY - JOUR

T1 - Proteins Associated with Neurodegenerative Diseases

T2 - Link to DNA Repair

AU - Khodyreva, Svetlana N.

AU - Dyrkheeva, Nadezhda S.

AU - Lavrik, Olga I.

N1 - Сведения о финансировании: Ministry of Education and Science of the Russian Federation

PY - 2024/12/11

Y1 - 2024/12/11

N2 - The nervous system is susceptible to DNA damage and DNA repair defects, and if DNA damage is not repaired, neuronal cells can die, causing neurodegenerative diseases in humans. The overall picture of what is known about DNA repair mechanisms in the nervous system is still unclear. The current challenge is to use the accumulated knowledge of basic science on DNA repair to improve the treatment of neurodegenerative disorders. In this review, we summarize the current understanding of the function of DNA damage repair, in particular, the base excision repair and double-strand break repair pathways as being the most important in nervous system cells. We summarize recent data on the proteins involved in DNA repair associated with neurodegenerative diseases, with particular emphasis on PARP1 and ND-associated proteins, which are involved in DNA repair and have the ability to undergo liquid–liquid phase separation.

AB - The nervous system is susceptible to DNA damage and DNA repair defects, and if DNA damage is not repaired, neuronal cells can die, causing neurodegenerative diseases in humans. The overall picture of what is known about DNA repair mechanisms in the nervous system is still unclear. The current challenge is to use the accumulated knowledge of basic science on DNA repair to improve the treatment of neurodegenerative disorders. In this review, we summarize the current understanding of the function of DNA damage repair, in particular, the base excision repair and double-strand break repair pathways as being the most important in nervous system cells. We summarize recent data on the proteins involved in DNA repair associated with neurodegenerative diseases, with particular emphasis on PARP1 and ND-associated proteins, which are involved in DNA repair and have the ability to undergo liquid–liquid phase separation.

KW - C9orf72

KW - FUS

KW - NONO

KW - SFPQ

KW - TDP-43

KW - alpha synuclein

KW - amyloid beta

KW - base excision repair

KW - direct DNA repair

KW - homologous recombination

KW - huntingtin

KW - liquid–liquid phase separation

KW - mismatch repair

KW - neurodegenerative disease

KW - nonhomologous end joining

KW - poly(ADP-ribose) polymerase 1

KW - tau protein

KW - alpha synuclein

KW - amyloid beta

KW - base excision repair

KW - C9orf72

KW - direct DNA repair

KW - FUS

KW - homologous recombination

KW - huntingtin

KW - liquid–liquid phase separation

KW - mismatch repair

KW - neurodegenerative disease

KW - nonhomologous end joining

KW - NONO

KW - poly(ADP-ribose) polymerase 1

KW - SFPQ

KW - tau protein

KW - TDP-43

UR - https://www.mendeley.com/catalogue/2a023eb8-dca0-3e9e-9df9-ad9f07e8b550/

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85213230985&origin=inward&txGid=c77c287521e03ebd11819ef5f736e74ahttps://www.scopus.com/record/display.uri?eid=2-s2.0-85213230985&origin=inward&txGid=c77c287521e03ebd11819ef5f736e74a

U2 - 10.3390/biomedicines12122808

DO - 10.3390/biomedicines12122808

M3 - Article

C2 - 39767715

VL - 12

JO - Biomedicines

JF - Biomedicines

SN - 2227-9059

IS - 12

M1 - 2808

ER -