Research output: Contribution to journal › Article › peer-review
Proteins Associated with Neurodegenerative Diseases : Link to DNA Repair. / Khodyreva, Svetlana N.; Dyrkheeva, Nadezhda S.; Lavrik, Olga I.
In: Biomedicines, Vol. 12, No. 12, 2808, 11.12.2024.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Proteins Associated with Neurodegenerative Diseases
T2 - Link to DNA Repair
AU - Khodyreva, Svetlana N.
AU - Dyrkheeva, Nadezhda S.
AU - Lavrik, Olga I.
N1 - Сведения о финансировании: Ministry of Education and Science of the Russian Federation
PY - 2024/12/11
Y1 - 2024/12/11
N2 - The nervous system is susceptible to DNA damage and DNA repair defects, and if DNA damage is not repaired, neuronal cells can die, causing neurodegenerative diseases in humans. The overall picture of what is known about DNA repair mechanisms in the nervous system is still unclear. The current challenge is to use the accumulated knowledge of basic science on DNA repair to improve the treatment of neurodegenerative disorders. In this review, we summarize the current understanding of the function of DNA damage repair, in particular, the base excision repair and double-strand break repair pathways as being the most important in nervous system cells. We summarize recent data on the proteins involved in DNA repair associated with neurodegenerative diseases, with particular emphasis on PARP1 and ND-associated proteins, which are involved in DNA repair and have the ability to undergo liquid–liquid phase separation.
AB - The nervous system is susceptible to DNA damage and DNA repair defects, and if DNA damage is not repaired, neuronal cells can die, causing neurodegenerative diseases in humans. The overall picture of what is known about DNA repair mechanisms in the nervous system is still unclear. The current challenge is to use the accumulated knowledge of basic science on DNA repair to improve the treatment of neurodegenerative disorders. In this review, we summarize the current understanding of the function of DNA damage repair, in particular, the base excision repair and double-strand break repair pathways as being the most important in nervous system cells. We summarize recent data on the proteins involved in DNA repair associated with neurodegenerative diseases, with particular emphasis on PARP1 and ND-associated proteins, which are involved in DNA repair and have the ability to undergo liquid–liquid phase separation.
KW - C9orf72
KW - FUS
KW - NONO
KW - SFPQ
KW - TDP-43
KW - alpha synuclein
KW - amyloid beta
KW - base excision repair
KW - direct DNA repair
KW - homologous recombination
KW - huntingtin
KW - liquid–liquid phase separation
KW - mismatch repair
KW - neurodegenerative disease
KW - nonhomologous end joining
KW - poly(ADP-ribose) polymerase 1
KW - tau protein
KW - alpha synuclein
KW - amyloid beta
KW - base excision repair
KW - C9orf72
KW - direct DNA repair
KW - FUS
KW - homologous recombination
KW - huntingtin
KW - liquid–liquid phase separation
KW - mismatch repair
KW - neurodegenerative disease
KW - nonhomologous end joining
KW - NONO
KW - poly(ADP-ribose) polymerase 1
KW - SFPQ
KW - tau protein
KW - TDP-43
UR - https://www.mendeley.com/catalogue/2a023eb8-dca0-3e9e-9df9-ad9f07e8b550/
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85213230985&origin=inward&txGid=c77c287521e03ebd11819ef5f736e74ahttps://www.scopus.com/record/display.uri?eid=2-s2.0-85213230985&origin=inward&txGid=c77c287521e03ebd11819ef5f736e74a
U2 - 10.3390/biomedicines12122808
DO - 10.3390/biomedicines12122808
M3 - Article
C2 - 39767715
VL - 12
JO - Biomedicines
JF - Biomedicines
SN - 2227-9059
IS - 12
M1 - 2808
ER -
ID: 61423371