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Pathology of A(H5N8) (Clade 2.3.4.4) Virus in Experimentally Infected Chickens and Mice. / Prokopyeva, Elena A.; Zinserling, Vsevolod A.; Bae, You Chan и др.

в: Interdisciplinary Perspectives on Infectious Diseases, Том 2019, 4124865, 01.01.2019, стр. 4124865.

Результаты исследований: Научные публикации в периодических изданияхстатьяРецензирование

Harvard

Prokopyeva, EA, Zinserling, VA, Bae, YC, Kwon, Y, Kurskaya, OG, Sobolev, IA, Kozhin, PM, Komissarov, A, Fadeev, A, Petrov, V, Shestopalov, AM & Sharshov, KA 2019, 'Pathology of A(H5N8) (Clade 2.3.4.4) Virus in Experimentally Infected Chickens and Mice', Interdisciplinary Perspectives on Infectious Diseases, Том. 2019, 4124865, стр. 4124865. https://doi.org/10.1155/2019/4124865

APA

Prokopyeva, E. A., Zinserling, V. A., Bae, Y. C., Kwon, Y., Kurskaya, O. G., Sobolev, I. A., Kozhin, P. M., Komissarov, A., Fadeev, A., Petrov, V., Shestopalov, A. M., & Sharshov, K. A. (2019). Pathology of A(H5N8) (Clade 2.3.4.4) Virus in Experimentally Infected Chickens and Mice. Interdisciplinary Perspectives on Infectious Diseases, 2019, 4124865. [4124865]. https://doi.org/10.1155/2019/4124865

Vancouver

Prokopyeva EA, Zinserling VA, Bae YC, Kwon Y, Kurskaya OG, Sobolev IA и др. Pathology of A(H5N8) (Clade 2.3.4.4) Virus in Experimentally Infected Chickens and Mice. Interdisciplinary Perspectives on Infectious Diseases. 2019 янв. 1;2019:4124865. 4124865. doi: 10.1155/2019/4124865

Author

Prokopyeva, Elena A. ; Zinserling, Vsevolod A. ; Bae, You Chan и др. / Pathology of A(H5N8) (Clade 2.3.4.4) Virus in Experimentally Infected Chickens and Mice. в: Interdisciplinary Perspectives on Infectious Diseases. 2019 ; Том 2019. стр. 4124865.

BibTeX

@article{6ae2cdd3098b433f8547b6a918aa5d69,
title = "Pathology of A(H5N8) (Clade 2.3.4.4) Virus in Experimentally Infected Chickens and Mice",
abstract = "The emergence of novel highly pathogenic avian influenza viruses (HPAIVs) in migratory birds raises serious concerns as these viruses have the potential to spread during fall migration. We report the identification of novel HPAIV A(H5N8) clade 2.3.4.4 virus that was isolated from sick domestic duck at commercial farm during the second wave of spread that began in October and affected poultry (ducks; chickens) in several European regions of Russia and Western Siberia in 2016. The strain was highly lethal in experimental infection of chickens and mice with IVPI = 2.34 and MLD50 = 1.3log10 = EID50, accordingly. Inoculation of chickens with the HPAIV A/H5N8 demonstrated neuroinvasiveness, multiorgan failure, and death of chickens on the 3rd day post inoculation. Virus replicated in all collected organ samples in high viral titers with the highest titer in the brain (6.75±0.1 log10 TCID50/ml). Effective virus replication was found in the following cells: neurons and glial cells of a brain; alveolar cells and macrophages of lungs; epithelial cells of a small intestine; hepatocytes and Kupffer cells of a liver; macrophages and endothelial cells of a spleen; and the tubular epithelial cells of kidneys. These findings advance our understanding of histopathological effect of A(H5N8) HPAIV infection.",
author = "Prokopyeva, {Elena A.} and Zinserling, {Vsevolod A.} and Bae, {You Chan} and Yongkuk Kwon and Kurskaya, {Olga G.} and Sobolev, {Ivan A.} and Kozhin, {Peter M.} and Andrey Komissarov and Artem Fadeev and Vladimir Petrov and Shestopalov, {Alexander M.} and Sharshov, {Kirill A.}",
year = "2019",
month = jan,
day = "1",
doi = "10.1155/2019/4124865",
language = "English",
volume = "2019",
pages = "4124865",
journal = "Interdisciplinary Perspectives on Infectious Diseases",
issn = "1687-708X",
publisher = "Hindawi Limited",

}

RIS

TY - JOUR

T1 - Pathology of A(H5N8) (Clade 2.3.4.4) Virus in Experimentally Infected Chickens and Mice

AU - Prokopyeva, Elena A.

AU - Zinserling, Vsevolod A.

AU - Bae, You Chan

AU - Kwon, Yongkuk

AU - Kurskaya, Olga G.

AU - Sobolev, Ivan A.

AU - Kozhin, Peter M.

AU - Komissarov, Andrey

AU - Fadeev, Artem

AU - Petrov, Vladimir

AU - Shestopalov, Alexander M.

AU - Sharshov, Kirill A.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - The emergence of novel highly pathogenic avian influenza viruses (HPAIVs) in migratory birds raises serious concerns as these viruses have the potential to spread during fall migration. We report the identification of novel HPAIV A(H5N8) clade 2.3.4.4 virus that was isolated from sick domestic duck at commercial farm during the second wave of spread that began in October and affected poultry (ducks; chickens) in several European regions of Russia and Western Siberia in 2016. The strain was highly lethal in experimental infection of chickens and mice with IVPI = 2.34 and MLD50 = 1.3log10 = EID50, accordingly. Inoculation of chickens with the HPAIV A/H5N8 demonstrated neuroinvasiveness, multiorgan failure, and death of chickens on the 3rd day post inoculation. Virus replicated in all collected organ samples in high viral titers with the highest titer in the brain (6.75±0.1 log10 TCID50/ml). Effective virus replication was found in the following cells: neurons and glial cells of a brain; alveolar cells and macrophages of lungs; epithelial cells of a small intestine; hepatocytes and Kupffer cells of a liver; macrophages and endothelial cells of a spleen; and the tubular epithelial cells of kidneys. These findings advance our understanding of histopathological effect of A(H5N8) HPAIV infection.

AB - The emergence of novel highly pathogenic avian influenza viruses (HPAIVs) in migratory birds raises serious concerns as these viruses have the potential to spread during fall migration. We report the identification of novel HPAIV A(H5N8) clade 2.3.4.4 virus that was isolated from sick domestic duck at commercial farm during the second wave of spread that began in October and affected poultry (ducks; chickens) in several European regions of Russia and Western Siberia in 2016. The strain was highly lethal in experimental infection of chickens and mice with IVPI = 2.34 and MLD50 = 1.3log10 = EID50, accordingly. Inoculation of chickens with the HPAIV A/H5N8 demonstrated neuroinvasiveness, multiorgan failure, and death of chickens on the 3rd day post inoculation. Virus replicated in all collected organ samples in high viral titers with the highest titer in the brain (6.75±0.1 log10 TCID50/ml). Effective virus replication was found in the following cells: neurons and glial cells of a brain; alveolar cells and macrophages of lungs; epithelial cells of a small intestine; hepatocytes and Kupffer cells of a liver; macrophages and endothelial cells of a spleen; and the tubular epithelial cells of kidneys. These findings advance our understanding of histopathological effect of A(H5N8) HPAIV infection.

UR - http://www.scopus.com/inward/record.url?scp=85069044516&partnerID=8YFLogxK

U2 - 10.1155/2019/4124865

DO - 10.1155/2019/4124865

M3 - Article

C2 - 31354812

AN - SCOPUS:85069044516

VL - 2019

SP - 4124865

JO - Interdisciplinary Perspectives on Infectious Diseases

JF - Interdisciplinary Perspectives on Infectious Diseases

SN - 1687-708X

M1 - 4124865

ER -

ID: 20885935