TY - JOUR

T1 - Parahydrogen-Induced Polarization of Amino Acids

AU - Pravdivtsev, Andrey N.

AU - Buntkowsky, Gerd

AU - Duckett, Simon B.

AU - Koptyug, Igor V.

AU - Hövener, Jan Bernd

N1 - Funding Information: A.P. and J.‐B.H. acknowledge funding from BMBF (01ZX1915C), DFG (HO‐4602/2‐2, HO‐4602/3, GRK2154‐2019, EXC PMI2167, FOR5042, TRR287), Kiel University, and the Faculty of Medicine for supporting the MOIN CC. I.V.K. acknowledges financial support from the Russian Foundation for Basic Research (#19‐53‐12013). G.B. acknowledges funding by the DFG (Bu911/22‐2 and Bu911/29‐1). We also acknowledge Julia Kugler for help with the frontispiece. Open access funding enabled and organized by Projekt DEAL. Publisher Copyright: © 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH

PY - 2021/10/25

Y1 - 2021/10/25

N2 - Nuclear magnetic resonance (NMR) has become a universal method for biochemical and biomedical studies, including metabolomics, proteomics, and magnetic resonance imaging (MRI). By increasing the signal of selected molecules, the hyperpolarization of nuclear spin has expanded the reach of NMR and MRI even further (e.g. hyperpolarized solid-state NMR and metabolic imaging in vivo). Parahydrogen (pH2) offers a fast and cost-efficient way to achieve hyperpolarization, and the last decade has seen extensive advances, including the synthesis of new tracers, catalysts, and transfer methods. The portfolio of hyperpolarized molecules now includes amino acids, which are of great interest for many applications. Here, we provide an overview of the current literature and developments in the hyperpolarization of amino acids and peptides.

AB - Nuclear magnetic resonance (NMR) has become a universal method for biochemical and biomedical studies, including metabolomics, proteomics, and magnetic resonance imaging (MRI). By increasing the signal of selected molecules, the hyperpolarization of nuclear spin has expanded the reach of NMR and MRI even further (e.g. hyperpolarized solid-state NMR and metabolic imaging in vivo). Parahydrogen (pH2) offers a fast and cost-efficient way to achieve hyperpolarization, and the last decade has seen extensive advances, including the synthesis of new tracers, catalysts, and transfer methods. The portfolio of hyperpolarized molecules now includes amino acids, which are of great interest for many applications. Here, we provide an overview of the current literature and developments in the hyperpolarization of amino acids and peptides.

KW - amino acids

KW - catalysis

KW - hydrogenation

KW - hyperpolarization

KW - parahydrogen

UR - http://www.scopus.com/inward/record.url?scp=85108795518&partnerID=8YFLogxK

U2 - 10.1002/anie.202100109

DO - 10.1002/anie.202100109

M3 - Review article

C2 - 33635601

AN - SCOPUS:85108795518

VL - 60

SP - 23496

EP - 23507

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 44

ER -