Research output: Contribution to journal › Review article › peer-review
Parahydrogen-Induced Polarization of Amino Acids. / Pravdivtsev, Andrey N.; Buntkowsky, Gerd; Duckett, Simon B. et al.
In: Angewandte Chemie - International Edition, Vol. 60, No. 44, 25.10.2021, p. 23496-23507.Research output: Contribution to journal › Review article › peer-review
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TY - JOUR
T1 - Parahydrogen-Induced Polarization of Amino Acids
AU - Pravdivtsev, Andrey N.
AU - Buntkowsky, Gerd
AU - Duckett, Simon B.
AU - Koptyug, Igor V.
AU - Hövener, Jan Bernd
N1 - Funding Information: A.P. and J.‐B.H. acknowledge funding from BMBF (01ZX1915C), DFG (HO‐4602/2‐2, HO‐4602/3, GRK2154‐2019, EXC PMI2167, FOR5042, TRR287), Kiel University, and the Faculty of Medicine for supporting the MOIN CC. I.V.K. acknowledges financial support from the Russian Foundation for Basic Research (#19‐53‐12013). G.B. acknowledges funding by the DFG (Bu911/22‐2 and Bu911/29‐1). We also acknowledge Julia Kugler for help with the frontispiece. Open access funding enabled and organized by Projekt DEAL. Publisher Copyright: © 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH
PY - 2021/10/25
Y1 - 2021/10/25
N2 - Nuclear magnetic resonance (NMR) has become a universal method for biochemical and biomedical studies, including metabolomics, proteomics, and magnetic resonance imaging (MRI). By increasing the signal of selected molecules, the hyperpolarization of nuclear spin has expanded the reach of NMR and MRI even further (e.g. hyperpolarized solid-state NMR and metabolic imaging in vivo). Parahydrogen (pH2) offers a fast and cost-efficient way to achieve hyperpolarization, and the last decade has seen extensive advances, including the synthesis of new tracers, catalysts, and transfer methods. The portfolio of hyperpolarized molecules now includes amino acids, which are of great interest for many applications. Here, we provide an overview of the current literature and developments in the hyperpolarization of amino acids and peptides.
AB - Nuclear magnetic resonance (NMR) has become a universal method for biochemical and biomedical studies, including metabolomics, proteomics, and magnetic resonance imaging (MRI). By increasing the signal of selected molecules, the hyperpolarization of nuclear spin has expanded the reach of NMR and MRI even further (e.g. hyperpolarized solid-state NMR and metabolic imaging in vivo). Parahydrogen (pH2) offers a fast and cost-efficient way to achieve hyperpolarization, and the last decade has seen extensive advances, including the synthesis of new tracers, catalysts, and transfer methods. The portfolio of hyperpolarized molecules now includes amino acids, which are of great interest for many applications. Here, we provide an overview of the current literature and developments in the hyperpolarization of amino acids and peptides.
KW - amino acids
KW - catalysis
KW - hydrogenation
KW - hyperpolarization
KW - parahydrogen
UR - http://www.scopus.com/inward/record.url?scp=85108795518&partnerID=8YFLogxK
U2 - 10.1002/anie.202100109
DO - 10.1002/anie.202100109
M3 - Review article
C2 - 33635601
AN - SCOPUS:85108795518
VL - 60
SP - 23496
EP - 23507
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
SN - 1433-7851
IS - 44
ER -
ID: 34209643