Результаты исследований: Научные публикации в периодических изданиях › обзорная статья › Рецензирование
Optigenetic approach in investigations of pathophysiology and therapy of depression. / Dygalo, N. N.; Shishkina, G. T.
в: Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova, Том 67, № 5, 2017, стр. 32-40.Результаты исследований: Научные публикации в периодических изданиях › обзорная статья › Рецензирование
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TY - JOUR
T1 - Optigenetic approach in investigations of pathophysiology and therapy of depression
AU - Dygalo, N. N.
AU - Shishkina, G. T.
PY - 2017
Y1 - 2017
N2 - Glutamatergic neurotransmission and neurotransmitter systems that operate together with it ensure the functioning of brain mechanisms that control the psychoemotional state. Currently, there is convincing evidence of involvement of the key brain structures regulating emotions, such as prefrontal cortex, hippocampus, nucleus accumbens, ventral tegmental area, the serotonergic raphe nuclei and amygdala in the pathogenesis of depression and the therapeutic effects of antidepressants. Disturbance of the balance between "exciting" and "inhibiting" signals to these areas, as evidenced by experimental and clinical data, obviously underlies depressive psychoemotional disorders. Efforts to unrevel the mechanisms of depression and antidepressant responses have received considerable support in connection with the development and implementation of optogenetic techniques in research practice. Studies of recent years, using an optogenetic approach that would facilitate the translation of their main results, considered in the review, to the clinic.
AB - Glutamatergic neurotransmission and neurotransmitter systems that operate together with it ensure the functioning of brain mechanisms that control the psychoemotional state. Currently, there is convincing evidence of involvement of the key brain structures regulating emotions, such as prefrontal cortex, hippocampus, nucleus accumbens, ventral tegmental area, the serotonergic raphe nuclei and amygdala in the pathogenesis of depression and the therapeutic effects of antidepressants. Disturbance of the balance between "exciting" and "inhibiting" signals to these areas, as evidenced by experimental and clinical data, obviously underlies depressive psychoemotional disorders. Efforts to unrevel the mechanisms of depression and antidepressant responses have received considerable support in connection with the development and implementation of optogenetic techniques in research practice. Studies of recent years, using an optogenetic approach that would facilitate the translation of their main results, considered in the review, to the clinic.
KW - Brain regions
KW - Depression
KW - Optogenetics
KW - Stress
KW - brain regions
KW - stress
KW - OPTOGENETIC STIMULATION
KW - BCL-XL
KW - optogenetics
KW - SUSCEPTIBILITY
KW - CIRCUITS
KW - SOCIAL DEFEAT
KW - GLUTAMATE
KW - MEDIAL PREFRONTAL CORTEX
KW - NEURONS
KW - depression
KW - DORSAL RAPHE NUCLEUS
KW - STRESS
UR - http://www.scopus.com/inward/record.url?scp=85041588850&partnerID=8YFLogxK
U2 - 10.7868/S0044467717050045
DO - 10.7868/S0044467717050045
M3 - Review article
AN - SCOPUS:85041588850
VL - 67
SP - 32
EP - 40
JO - Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova
JF - Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova
SN - 0044-4677
IS - 5
ER -
ID: 9640379