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Optigenetic approach in investigations of pathophysiology and therapy of depression. / Dygalo, N. N.; Shishkina, G. T.

In: Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova, Vol. 67, No. 5, 2017, p. 32-40.

Research output: Contribution to journal › Review article › peer-review

Harvard

Dygalo, NN & Shishkina, GT 2017, 'Optigenetic approach in investigations of pathophysiology and therapy of depression', Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova, vol. 67, no. 5, pp. 32-40. https://doi.org/10.7868/S0044467717050045

APA

Dygalo, N. N., & Shishkina, G. T. (2017). Optigenetic approach in investigations of pathophysiology and therapy of depression. Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova, 67(5), 32-40. https://doi.org/10.7868/S0044467717050045

Vancouver

Dygalo NN, Shishkina GT. Optigenetic approach in investigations of pathophysiology and therapy of depression. Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 2017;67(5):32-40. doi: 10.7868/S0044467717050045

Author

Dygalo, N. N. ; Shishkina, G. T. / Optigenetic approach in investigations of pathophysiology and therapy of depression. In: Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 2017 ; Vol. 67, No. 5. pp. 32-40.

BibTeX

@article{5ebdfd470d374778b620e113a0f76f80,
title = "Optigenetic approach in investigations of pathophysiology and therapy of depression",
abstract = "Glutamatergic neurotransmission and neurotransmitter systems that operate together with it ensure the functioning of brain mechanisms that control the psychoemotional state. Currently, there is convincing evidence of involvement of the key brain structures regulating emotions, such as prefrontal cortex, hippocampus, nucleus accumbens, ventral tegmental area, the serotonergic raphe nuclei and amygdala in the pathogenesis of depression and the therapeutic effects of antidepressants. Disturbance of the balance between {"}exciting{"} and {"}inhibiting{"} signals to these areas, as evidenced by experimental and clinical data, obviously underlies depressive psychoemotional disorders. Efforts to unrevel the mechanisms of depression and antidepressant responses have received considerable support in connection with the development and implementation of optogenetic techniques in research practice. Studies of recent years, using an optogenetic approach that would facilitate the translation of their main results, considered in the review, to the clinic.",
keywords = "Brain regions, Depression, Optogenetics, Stress, brain regions, stress, OPTOGENETIC STIMULATION, BCL-XL, optogenetics, SUSCEPTIBILITY, CIRCUITS, SOCIAL DEFEAT, GLUTAMATE, MEDIAL PREFRONTAL CORTEX, NEURONS, depression, DORSAL RAPHE NUCLEUS, STRESS",
author = "Dygalo, {N. N.} and Shishkina, {G. T.}",
year = "2017",
doi = "10.7868/S0044467717050045",
language = "English",
volume = "67",
pages = "32--40",
journal = "Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova",
issn = "0044-4677",
publisher = "MEZHDUNARODNAYA KNIGA",
number = "5",

}

RIS

TY - JOUR

T1 - Optigenetic approach in investigations of pathophysiology and therapy of depression

AU - Dygalo, N. N.

AU - Shishkina, G. T.

PY - 2017

Y1 - 2017

N2 - Glutamatergic neurotransmission and neurotransmitter systems that operate together with it ensure the functioning of brain mechanisms that control the psychoemotional state. Currently, there is convincing evidence of involvement of the key brain structures regulating emotions, such as prefrontal cortex, hippocampus, nucleus accumbens, ventral tegmental area, the serotonergic raphe nuclei and amygdala in the pathogenesis of depression and the therapeutic effects of antidepressants. Disturbance of the balance between "exciting" and "inhibiting" signals to these areas, as evidenced by experimental and clinical data, obviously underlies depressive psychoemotional disorders. Efforts to unrevel the mechanisms of depression and antidepressant responses have received considerable support in connection with the development and implementation of optogenetic techniques in research practice. Studies of recent years, using an optogenetic approach that would facilitate the translation of their main results, considered in the review, to the clinic.

AB - Glutamatergic neurotransmission and neurotransmitter systems that operate together with it ensure the functioning of brain mechanisms that control the psychoemotional state. Currently, there is convincing evidence of involvement of the key brain structures regulating emotions, such as prefrontal cortex, hippocampus, nucleus accumbens, ventral tegmental area, the serotonergic raphe nuclei and amygdala in the pathogenesis of depression and the therapeutic effects of antidepressants. Disturbance of the balance between "exciting" and "inhibiting" signals to these areas, as evidenced by experimental and clinical data, obviously underlies depressive psychoemotional disorders. Efforts to unrevel the mechanisms of depression and antidepressant responses have received considerable support in connection with the development and implementation of optogenetic techniques in research practice. Studies of recent years, using an optogenetic approach that would facilitate the translation of their main results, considered in the review, to the clinic.

KW - Brain regions

KW - Depression

KW - Optogenetics

KW - Stress

KW - brain regions

KW - stress

KW - OPTOGENETIC STIMULATION

KW - BCL-XL

KW - optogenetics

KW - SUSCEPTIBILITY

KW - CIRCUITS

KW - SOCIAL DEFEAT

KW - GLUTAMATE

KW - MEDIAL PREFRONTAL CORTEX

KW - NEURONS

KW - depression

KW - DORSAL RAPHE NUCLEUS

KW - STRESS

UR - http://www.scopus.com/inward/record.url?scp=85041588850&partnerID=8YFLogxK

U2 - 10.7868/S0044467717050045

DO - 10.7868/S0044467717050045

M3 - Review article

AN - SCOPUS:85041588850

VL - 67

SP - 32

EP - 40

JO - Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova

JF - Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova

SN - 0044-4677

IS - 5

ER -

ID: 9640379