Результаты исследований: Научные публикации в периодических изданиях › обзорная статья › Рецензирование
Noncanonical constitutive androstane receptor signaling in gene regulation. / Pustylnyak, Yuliya A.; Gulyaeva, Lyudmila F.; Pustylnyak, Vladimir O.
в: International Journal of Molecular Sciences, Том 21, № 18, 6735, 14.09.2020, стр. 1-10.Результаты исследований: Научные публикации в периодических изданиях › обзорная статья › Рецензирование
}
TY - JOUR
T1 - Noncanonical constitutive androstane receptor signaling in gene regulation
AU - Pustylnyak, Yuliya A.
AU - Gulyaeva, Lyudmila F.
AU - Pustylnyak, Vladimir O.
PY - 2020/9/14
Y1 - 2020/9/14
N2 - The constitutive androstane receptor (CAR, NR1I3) is extremely important for the regulation of many physiological processes, especially xenobiotic (drug) metabolism and transporters. CAR differs from steroid hormone receptors in that it can be activated using structurally unrelated chemicals, both through direct ligand-binding and ligand-independent (indirect) mechanisms. By binding to specific responsive elements on DNA, CAR increases the expression of its target genes encoding drug-metabolizing enzymes and transporters. Therefore, CAR is mainly characterized as a ligand-dependent or ligand-independent transcription factor, and the induction of gene expression is considered the canonical mode of CAR action. Consistent with its central role in xenobiotic metabolism, CAR signaling includes a collection of mechanisms that are employed alongside the core transcriptional machinery of the receptor. These so-called noncanonical CAR pathways allow the receptor to coordinate the regulation of many aspects of cell biology. In this mini-review, we review noncanonical CAR signaling, paying special attention to the role of CAR in energy homeostasis and cell proliferation.
AB - The constitutive androstane receptor (CAR, NR1I3) is extremely important for the regulation of many physiological processes, especially xenobiotic (drug) metabolism and transporters. CAR differs from steroid hormone receptors in that it can be activated using structurally unrelated chemicals, both through direct ligand-binding and ligand-independent (indirect) mechanisms. By binding to specific responsive elements on DNA, CAR increases the expression of its target genes encoding drug-metabolizing enzymes and transporters. Therefore, CAR is mainly characterized as a ligand-dependent or ligand-independent transcription factor, and the induction of gene expression is considered the canonical mode of CAR action. Consistent with its central role in xenobiotic metabolism, CAR signaling includes a collection of mechanisms that are employed alongside the core transcriptional machinery of the receptor. These so-called noncanonical CAR pathways allow the receptor to coordinate the regulation of many aspects of cell biology. In this mini-review, we review noncanonical CAR signaling, paying special attention to the role of CAR in energy homeostasis and cell proliferation.
KW - CAR
KW - Cell proliferation
KW - Energy homeostasis
KW - Gene regulation
KW - Noncanonical signaling
UR - http://www.scopus.com/inward/record.url?scp=85090862002&partnerID=8YFLogxK
U2 - 10.3390/ijms21186735
DO - 10.3390/ijms21186735
M3 - Review article
C2 - 32937916
AN - SCOPUS:85090862002
VL - 21
SP - 1
EP - 10
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1661-6596
IS - 18
M1 - 6735
ER -
ID: 25297859