TY - JOUR

T1 - Nitric Oxide Photorelease from Silicone Films Doped with N-Nitroso BODIPY

AU - Virts, Natalia A.

AU - Karogodina, Tatyana Yu

AU - Panfilov, Mikhail A.

AU - Vorob’ev, Alexey Yu

AU - Moskalensky, Alexander E.

N1 - The study was supported by the Russian Science Foundation (grant #23-75-10049).

PY - 2024/4

Y1 - 2024/4

N2 - Nitric oxide (NO) is a unique biochemical mediator involved in the regulation of vital processes. Light-controllable NO releasers show promise in the development of smart therapies. Here, we present a novel biocompatible material based on polydimethylsiloxane (PDMS) doped with BODIPY derivatives containing an N-nitroso moiety that is capable of the photoinduced generation of NO. We study the green-light-induced NO-release properties with the following three methods: electrochemical gas-phase sensor, liquid-phase sensor, and the Griess assay. Prolonged release of NO from the polymer films after short irradiation by narrow-band LED light sources and a laser beam is demonstrated. Importantly, this was accompanied by no or little release of the parent compound (BODIPY-based photodonor). Silicone films with the capability of controllable and clean NO release can potentially be used as a highly portable NO delivery system for different therapeutic applications.

AB - Nitric oxide (NO) is a unique biochemical mediator involved in the regulation of vital processes. Light-controllable NO releasers show promise in the development of smart therapies. Here, we present a novel biocompatible material based on polydimethylsiloxane (PDMS) doped with BODIPY derivatives containing an N-nitroso moiety that is capable of the photoinduced generation of NO. We study the green-light-induced NO-release properties with the following three methods: electrochemical gas-phase sensor, liquid-phase sensor, and the Griess assay. Prolonged release of NO from the polymer films after short irradiation by narrow-band LED light sources and a laser beam is demonstrated. Importantly, this was accompanied by no or little release of the parent compound (BODIPY-based photodonor). Silicone films with the capability of controllable and clean NO release can potentially be used as a highly portable NO delivery system for different therapeutic applications.

KW - BODIPY

KW - NO photodonor

KW - nitric oxide

KW - photopharmacology

KW - silicone

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85191536872&origin=inward&txGid=c7807440ad516203d675c2d31358203e

UR - https://www.mendeley.com/catalogue/7c51e39d-018d-3044-a7aa-a97211655942/

U2 - 10.3390/jfb15040092

DO - 10.3390/jfb15040092

M3 - Article

C2 - 38667549

VL - 15

JO - Journal of Functional Biomaterials

JF - Journal of Functional Biomaterials

SN - 2079-4983

IS - 4

M1 - 92

ER -