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Nitric Oxide Photorelease from Silicone Films Doped with N-Nitroso BODIPY. / Virts, Natalia A.; Karogodina, Tatyana Yu; Panfilov, Mikhail A. et al.

In: Journal of Functional Biomaterials, Vol. 15, No. 4, 92, 04.2024.

Research output: Contribution to journal › Article › peer-review

Harvard

Virts, NA, Karogodina, TY, Panfilov, MA, Vorob’ev, AY & Moskalensky, AE 2024, 'Nitric Oxide Photorelease from Silicone Films Doped with N-Nitroso BODIPY', Journal of Functional Biomaterials, vol. 15, no. 4, 92. https://doi.org/10.3390/jfb15040092

APA

Virts, N. A., Karogodina, T. Y., Panfilov, M. A., Vorob’ev, A. Y., & Moskalensky, A. E. (2024). Nitric Oxide Photorelease from Silicone Films Doped with N-Nitroso BODIPY. Journal of Functional Biomaterials, 15(4), [92]. https://doi.org/10.3390/jfb15040092

Vancouver

Virts NA, Karogodina TY, Panfilov MA, Vorob’ev AY, Moskalensky AE. Nitric Oxide Photorelease from Silicone Films Doped with N-Nitroso BODIPY. Journal of Functional Biomaterials. 2024 Apr;15(4):92. doi: 10.3390/jfb15040092

Author

Virts, Natalia A. ; Karogodina, Tatyana Yu ; Panfilov, Mikhail A. et al. / Nitric Oxide Photorelease from Silicone Films Doped with N-Nitroso BODIPY. In: Journal of Functional Biomaterials. 2024 ; Vol. 15, No. 4.

BibTeX

@article{e92e4c553197464cba75d1486d0cb1e9,
title = "Nitric Oxide Photorelease from Silicone Films Doped with N-Nitroso BODIPY",
abstract = "Nitric oxide (NO) is a unique biochemical mediator involved in the regulation of vital processes. Light-controllable NO releasers show promise in the development of smart therapies. Here, we present a novel biocompatible material based on polydimethylsiloxane (PDMS) doped with BODIPY derivatives containing an N-nitroso moiety that is capable of the photoinduced generation of NO. We study the green-light-induced NO-release properties with the following three methods: electrochemical gas-phase sensor, liquid-phase sensor, and the Griess assay. Prolonged release of NO from the polymer films after short irradiation by narrow-band LED light sources and a laser beam is demonstrated. Importantly, this was accompanied by no or little release of the parent compound (BODIPY-based photodonor). Silicone films with the capability of controllable and clean NO release can potentially be used as a highly portable NO delivery system for different therapeutic applications.",
keywords = "BODIPY, NO photodonor, nitric oxide, photopharmacology, silicone",
author = "Virts, {Natalia A.} and Karogodina, {Tatyana Yu} and Panfilov, {Mikhail A.} and Vorob{\textquoteright}ev, {Alexey Yu} and Moskalensky, {Alexander E.}",
note = "The study was supported by the Russian Science Foundation (grant #23-75-10049).",
year = "2024",
month = apr,
doi = "10.3390/jfb15040092",
language = "English",
volume = "15",
journal = "Journal of Functional Biomaterials",
issn = "2079-4983",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "4",

}

RIS

TY - JOUR

T1 - Nitric Oxide Photorelease from Silicone Films Doped with N-Nitroso BODIPY

AU - Virts, Natalia A.

AU - Karogodina, Tatyana Yu

AU - Panfilov, Mikhail A.

AU - Vorob’ev, Alexey Yu

AU - Moskalensky, Alexander E.

N1 - The study was supported by the Russian Science Foundation (grant #23-75-10049).

PY - 2024/4

Y1 - 2024/4

N2 - Nitric oxide (NO) is a unique biochemical mediator involved in the regulation of vital processes. Light-controllable NO releasers show promise in the development of smart therapies. Here, we present a novel biocompatible material based on polydimethylsiloxane (PDMS) doped with BODIPY derivatives containing an N-nitroso moiety that is capable of the photoinduced generation of NO. We study the green-light-induced NO-release properties with the following three methods: electrochemical gas-phase sensor, liquid-phase sensor, and the Griess assay. Prolonged release of NO from the polymer films after short irradiation by narrow-band LED light sources and a laser beam is demonstrated. Importantly, this was accompanied by no or little release of the parent compound (BODIPY-based photodonor). Silicone films with the capability of controllable and clean NO release can potentially be used as a highly portable NO delivery system for different therapeutic applications.

AB - Nitric oxide (NO) is a unique biochemical mediator involved in the regulation of vital processes. Light-controllable NO releasers show promise in the development of smart therapies. Here, we present a novel biocompatible material based on polydimethylsiloxane (PDMS) doped with BODIPY derivatives containing an N-nitroso moiety that is capable of the photoinduced generation of NO. We study the green-light-induced NO-release properties with the following three methods: electrochemical gas-phase sensor, liquid-phase sensor, and the Griess assay. Prolonged release of NO from the polymer films after short irradiation by narrow-band LED light sources and a laser beam is demonstrated. Importantly, this was accompanied by no or little release of the parent compound (BODIPY-based photodonor). Silicone films with the capability of controllable and clean NO release can potentially be used as a highly portable NO delivery system for different therapeutic applications.

KW - BODIPY

KW - NO photodonor

KW - nitric oxide

KW - photopharmacology

KW - silicone

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85191536872&origin=inward&txGid=c7807440ad516203d675c2d31358203e

UR - https://www.mendeley.com/catalogue/7c51e39d-018d-3044-a7aa-a97211655942/

U2 - 10.3390/jfb15040092

DO - 10.3390/jfb15040092

M3 - Article

C2 - 38667549

VL - 15

JO - Journal of Functional Biomaterials

JF - Journal of Functional Biomaterials

SN - 2079-4983

IS - 4

M1 - 92

ER -

ID: 61084661