Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Neural response to catecholamine depletion in remitted bulimia nervosa : Relation to depression and relapse. / Ermakov, E.; Smirnova, L.; Ivanova, S. и др.
в: European Neuropsychopharmacology, Том 27, № 7, P.1.f.019, 01.07.2017, стр. 633-646.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Neural response to catecholamine depletion in remitted bulimia nervosa
T2 - 30th Congress of the European-College-of-Neuropsychopharmacology (ECNP)
AU - Ermakov, E.
AU - Smirnova, L.
AU - Ivanova, S.
AU - Zaharova, O.
AU - Buneva, V.
AU - Nevinsky, G.
N1 - Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Introduction: Schizophrenia is known to be a multifactorial disease associated with a violation of neurotransmitter processes and synaptic plasticity in the central nervous system, as well as dysregulation in the humoral immune system. Genome-wide association study of SNPs showed that in schizophrenia there is an association with the genes of the immune system and microRNAs [1]. Recently, catalytic antibodies or abzymes hydrolyzing DNA were found in the serum of patients with schizophrenia [2]. It is known that manipulating the levels of microRNA in the brain can alter the behavior [3]. Antibodies with nuclease activity may possibly destroy circulating regulatory nucleic acids and can play a role in behavioral disorders.Objectives: To investigate (a) DNA- and RNA-hydrolyzing activity of IgG antibodies isolated from the serum of patients with schizophrenia; (b) the cytotoxicity of isolated IgG on the human glioblastoma cell culture T98G.
AB - Introduction: Schizophrenia is known to be a multifactorial disease associated with a violation of neurotransmitter processes and synaptic plasticity in the central nervous system, as well as dysregulation in the humoral immune system. Genome-wide association study of SNPs showed that in schizophrenia there is an association with the genes of the immune system and microRNAs [1]. Recently, catalytic antibodies or abzymes hydrolyzing DNA were found in the serum of patients with schizophrenia [2]. It is known that manipulating the levels of microRNA in the brain can alter the behavior [3]. Antibodies with nuclease activity may possibly destroy circulating regulatory nucleic acids and can play a role in behavioral disorders.Objectives: To investigate (a) DNA- and RNA-hydrolyzing activity of IgG antibodies isolated from the serum of patients with schizophrenia; (b) the cytotoxicity of isolated IgG on the human glioblastoma cell culture T98G.
KW - IgG antibodies
KW - nuclease activivty
KW - abzymes
UR - https://www.webofscience.com/wos/author/record/660484
U2 - 10.1016/j.euroneuro.2017.04.002
DO - 10.1016/j.euroneuro.2017.04.002
M3 - Article
C2 - 28502528
VL - 27
SP - 633
EP - 646
JO - European Neuropsychopharmacology
JF - European Neuropsychopharmacology
SN - 0924-977X
IS - 7
M1 - P.1.f.019
Y2 - 2 September 2017 through 5 September 2017
ER -
ID: 18734049