Research output: Contribution to journal › Article › peer-review
Neural response to catecholamine depletion in remitted bulimia nervosa : Relation to depression and relapse. / Ermakov, E.; Smirnova, L.; Ivanova, S. et al.
In: European Neuropsychopharmacology, Vol. 27, No. 7, 01.07.2017, p. 633-646.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Neural response to catecholamine depletion in remitted bulimia nervosa
T2 - 30th Congress of the European-College-of-Neuropsychopharmacology (ECNP)
AU - Ermakov, E.
AU - Smirnova, L.
AU - Ivanova, S.
AU - Zaharova, O.
AU - Buneva, V.
AU - Nevinsky, G.
N1 - Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Bulimia nervosa has been associated with a dysregulated catecholamine system. Nevertheless, the influence of this dysregulation on bulimic symptoms, on neural activity, and on the course of the illness is not clear yet. An instructive paradigm for directly investigating the relationship between catecholaminergic functioning and bulimia nervosa has involved the behavioral and neural responses to experimental catecholamine depletion. The purpose of this study was to examine the neural substrate of catecholaminergic dysfunction in bulimia nervosa and its relationship to relapse. In a randomized, double-blind and crossover study design, catecholamine depletion was achieved by using the oral administration of alpha-methyl-paratyrosine (AMPT) over 24 h in 18 remitted bulimic (rBN) and 22 healthy (HC) female participants. Cerebral blood flow (CBF) was measured using a pseudo continuous arterial spin labeling (pCASL) sequence. In a follow-up telephone interview, bulimic relapse was assessed. Following AMPT, rBN participants revealed an increased vigor reduction and CBF decreases in the pallidum and posterior midcingulate cortex (pMCC) relative to HC participants showing no CBF changes in these regions. These results indicated that the pallidum and the pMCC are the functional neural correlates of the dysregulated catecholamine system in bulimia nervosa. Bulimic relapse was associated with increased depressive symptoms and CBF reduction in the hippocampus/parahippocampal gyrus following catecholamine depletion. AMPT-induced increased CBF in this region predicted staying in remission. These findings demonstrated the importance of depressive symptoms and the stress system in the course of bulimia nervosa.
AB - Bulimia nervosa has been associated with a dysregulated catecholamine system. Nevertheless, the influence of this dysregulation on bulimic symptoms, on neural activity, and on the course of the illness is not clear yet. An instructive paradigm for directly investigating the relationship between catecholaminergic functioning and bulimia nervosa has involved the behavioral and neural responses to experimental catecholamine depletion. The purpose of this study was to examine the neural substrate of catecholaminergic dysfunction in bulimia nervosa and its relationship to relapse. In a randomized, double-blind and crossover study design, catecholamine depletion was achieved by using the oral administration of alpha-methyl-paratyrosine (AMPT) over 24 h in 18 remitted bulimic (rBN) and 22 healthy (HC) female participants. Cerebral blood flow (CBF) was measured using a pseudo continuous arterial spin labeling (pCASL) sequence. In a follow-up telephone interview, bulimic relapse was assessed. Following AMPT, rBN participants revealed an increased vigor reduction and CBF decreases in the pallidum and posterior midcingulate cortex (pMCC) relative to HC participants showing no CBF changes in these regions. These results indicated that the pallidum and the pMCC are the functional neural correlates of the dysregulated catecholamine system in bulimia nervosa. Bulimic relapse was associated with increased depressive symptoms and CBF reduction in the hippocampus/parahippocampal gyrus following catecholamine depletion. AMPT-induced increased CBF in this region predicted staying in remission. These findings demonstrated the importance of depressive symptoms and the stress system in the course of bulimia nervosa.
KW - Alpha-methyl-paratyrosine
KW - Arterial spin labeling
KW - Bulimia nervosa
KW - Catecholamine depletion
KW - Cerebral blood flow
KW - Relapse
KW - Recurrence
KW - Double-Blind Method
KW - Follow-Up Studies
KW - Humans
KW - Middle Aged
KW - Remission Induction
KW - Cross-Over Studies
KW - Young Adult
KW - Brain/diagnostic imaging
KW - Bulimia Nervosa/blood
KW - Catecholamines/blood
KW - Adult
KW - Female
KW - Depression/blood
UR - http://www.scopus.com/inward/record.url?scp=85019109465&partnerID=8YFLogxK
U2 - 10.1016/j.euroneuro.2017.04.002
DO - 10.1016/j.euroneuro.2017.04.002
M3 - Article
C2 - 28502528
VL - 27
SP - 633
EP - 646
JO - European Neuropsychopharmacology
JF - European Neuropsychopharmacology
SN - 0924-977X
IS - 7
Y2 - 2 September 2017 through 5 September 2017
ER -
ID: 18734049