TY - JOUR

T1 - Multicompartmental Mathematical Model of SARS-CoV-2 Distribution in Human Organs and Their Treatment

AU - Afonyushkin, V. N.

AU - Акбердин, Илья Ринатович

AU - Kozlova, Yu

AU - Щукин, Иван Андреевич

AU - Mironova, Tatyana

AU - Bobikova, Anna

AU - Cherepushkina, Viktoriya

AU - Donchenko, Nikolaj

AU - Poletaeva, Yuliya E.

AU - Колпаков, Федор

N1 - Funding Information: This research was funded by RFBR, grant number 20-04-60355, “Development of a multiscale immuno-epidemiological mathematical model COVID-19, taking into account the impact on the economy of the region and the scenarios of authority actions”. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2022/6/1

Y1 - 2022/6/1

N2 - Patients with COVID-19 can develop pneumonia, severe symptoms of acute respiratory distress syndrome, and multiple organ failure. Nevertheless, the variety of forms of this disease requires further research on the pathogenesis of this disease. Based on the analysis of published data and original experiments on the concentrations of SARS-CoV-2 in biological fluids of the nasopharynx, lungs, and intestines and using a developed modular model of the virus distribution in human tissue and organs, an assessment of the SARS-CoV-2 reproduction in various compartments of the body is presented. Most of the viral particles can transport to the esophagus from the nasopharynx. The viral particles entering the gastrointestinal tract will obviously be accompanied by the infection of the intestinal epithelium and accumulation of the virus in the intestinal lumen in an amount proportional to their secretory and protein-synthetic activities. The relatively low concentration of SARS-CoV-2 in tissues implies an essential role of transport processes and redistribution of the virus from the nasopharynx and intestines to the lungs. The model simulations also suppose that sanitation of the nasopharynx mucosa at the initial stage of the infectious process has prospects for the use in medical practice.

AB - Patients with COVID-19 can develop pneumonia, severe symptoms of acute respiratory distress syndrome, and multiple organ failure. Nevertheless, the variety of forms of this disease requires further research on the pathogenesis of this disease. Based on the analysis of published data and original experiments on the concentrations of SARS-CoV-2 in biological fluids of the nasopharynx, lungs, and intestines and using a developed modular model of the virus distribution in human tissue and organs, an assessment of the SARS-CoV-2 reproduction in various compartments of the body is presented. Most of the viral particles can transport to the esophagus from the nasopharynx. The viral particles entering the gastrointestinal tract will obviously be accompanied by the infection of the intestinal epithelium and accumulation of the virus in the intestinal lumen in an amount proportional to their secretory and protein-synthetic activities. The relatively low concentration of SARS-CoV-2 in tissues implies an essential role of transport processes and redistribution of the virus from the nasopharynx and intestines to the lungs. The model simulations also suppose that sanitation of the nasopharynx mucosa at the initial stage of the infectious process has prospects for the use in medical practice.

KW - COVID-19

KW - Immunology

KW - Intestines

KW - Lungs

KW - Mathematical modeling

KW - Modular approach

KW - Nasopharynx

KW - Pathophysiology of COVID-19

KW - SARS-CoV-2

UR - http://www.scopus.com/inward/record.url?scp=85133655235&partnerID=8YFLogxK

U2 - 10.3390/math10111925

DO - 10.3390/math10111925

M3 - Article

VL - 10

JO - Mathematics

JF - Mathematics

SN - 2227-7390

IS - 11

M1 - 1925

ER -