Research output: Contribution to journal › Article › peer-review
Multicompartmental Mathematical Model of SARS-CoV-2 Distribution in Human Organs and Their Treatment. / Afonyushkin, V. N.; Акбердин, Илья Ринатович; Kozlova, Yu et al.
In: Mathematics, Vol. 10, No. 11, 1925, 01.06.2022.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Multicompartmental Mathematical Model of SARS-CoV-2 Distribution in Human Organs and Their Treatment
AU - Afonyushkin, V. N.
AU - Акбердин, Илья Ринатович
AU - Kozlova, Yu
AU - Щукин, Иван Андреевич
AU - Mironova, Tatyana
AU - Bobikova, Anna
AU - Cherepushkina, Viktoriya
AU - Donchenko, Nikolaj
AU - Poletaeva, Yuliya E.
AU - Колпаков, Федор
N1 - Funding Information: This research was funded by RFBR, grant number 20-04-60355, “Development of a multiscale immuno-epidemiological mathematical model COVID-19, taking into account the impact on the economy of the region and the scenarios of authority actions”. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/6/1
Y1 - 2022/6/1
N2 - Patients with COVID-19 can develop pneumonia, severe symptoms of acute respiratory distress syndrome, and multiple organ failure. Nevertheless, the variety of forms of this disease requires further research on the pathogenesis of this disease. Based on the analysis of published data and original experiments on the concentrations of SARS-CoV-2 in biological fluids of the nasopharynx, lungs, and intestines and using a developed modular model of the virus distribution in human tissue and organs, an assessment of the SARS-CoV-2 reproduction in various compartments of the body is presented. Most of the viral particles can transport to the esophagus from the nasopharynx. The viral particles entering the gastrointestinal tract will obviously be accompanied by the infection of the intestinal epithelium and accumulation of the virus in the intestinal lumen in an amount proportional to their secretory and protein-synthetic activities. The relatively low concentration of SARS-CoV-2 in tissues implies an essential role of transport processes and redistribution of the virus from the nasopharynx and intestines to the lungs. The model simulations also suppose that sanitation of the nasopharynx mucosa at the initial stage of the infectious process has prospects for the use in medical practice.
AB - Patients with COVID-19 can develop pneumonia, severe symptoms of acute respiratory distress syndrome, and multiple organ failure. Nevertheless, the variety of forms of this disease requires further research on the pathogenesis of this disease. Based on the analysis of published data and original experiments on the concentrations of SARS-CoV-2 in biological fluids of the nasopharynx, lungs, and intestines and using a developed modular model of the virus distribution in human tissue and organs, an assessment of the SARS-CoV-2 reproduction in various compartments of the body is presented. Most of the viral particles can transport to the esophagus from the nasopharynx. The viral particles entering the gastrointestinal tract will obviously be accompanied by the infection of the intestinal epithelium and accumulation of the virus in the intestinal lumen in an amount proportional to their secretory and protein-synthetic activities. The relatively low concentration of SARS-CoV-2 in tissues implies an essential role of transport processes and redistribution of the virus from the nasopharynx and intestines to the lungs. The model simulations also suppose that sanitation of the nasopharynx mucosa at the initial stage of the infectious process has prospects for the use in medical practice.
KW - COVID-19
KW - Immunology
KW - Intestines
KW - Lungs
KW - Mathematical modeling
KW - Modular approach
KW - Nasopharynx
KW - Pathophysiology of COVID-19
KW - SARS-CoV-2
UR - http://www.scopus.com/inward/record.url?scp=85133655235&partnerID=8YFLogxK
U2 - 10.3390/math10111925
DO - 10.3390/math10111925
M3 - Article
VL - 10
JO - Mathematics
JF - Mathematics
SN - 2227-7390
IS - 11
M1 - 1925
ER -
ID: 36191691