Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Molecular mechanisms of exceptional lifespan increase of Drosophila melanogaster with different genotypes after combinations of pro-longevity interventions. / Shaposhnikov, Mikhail V.; Guvatova, Zulfiya G.; Zemskaya, Nadezhda V. и др.
в: Communications Biology, Том 5, № 1, 566, 12.2022.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Molecular mechanisms of exceptional lifespan increase of Drosophila melanogaster with different genotypes after combinations of pro-longevity interventions
AU - Shaposhnikov, Mikhail V.
AU - Guvatova, Zulfiya G.
AU - Zemskaya, Nadezhda V.
AU - Koval, Liubov A.
AU - Schegoleva, Eugenia V.
AU - Gorbunova, Anastasia A.
AU - Golubev, Denis A.
AU - Pakshina, Natalya R.
AU - Ulyasheva, Natalia S.
AU - Solovev, Ilya A.
AU - Bobrovskikh, Margarita A.
AU - Gruntenko, Nataly E.
AU - Menshanov, Petr N.
AU - Krasnov, George S.
AU - Kudryavseva, Anna V.
AU - Moskalev, Alexey A.
N1 - Funding Information: We thank the Center for Precision Genome Editing and Genetic Technologies for Biomedicine, EIMB RAS for providing the computing power and sequencing data analysis. The sequencing was performed using the equipment of EIMB RAS “Genome” center (http://www.eimb.ru/ru1/ckp/ccu_genome_c.php ). The authors would like to thank Nicolay Sidorov for his assistance in purchasing of research reagents at the initial stage of the project. The study was carried out within the framework of the state task on themes “Genetic and functional studies of the effects of geroprotective interventions on the Drosophila melanogaster model”, N 122040600022-1. The analyses of total lipids content were performed by N.E.G, M.A.B. & P.N.M. with support from #FWNR-2022-0019 MSHE project. Publisher Copyright: © 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Aging is one of the global challenges of our time. The search for new anti-aging interventions is also an issue of great actuality. We report on the success of Drosophila melanogaster lifespan extension under the combined influence of dietary restriction, co-administration of berberine, fucoxanthin, and rapamycin, photodeprivation, and low-temperature conditions up to 185 days in w1118 strain and up to 213 days in long-lived E(z)/w mutants. The trade-off was found between longevity and locomotion. The transcriptome analysis showed an impact of epigenetic alterations, lipid metabolism, cellular respiration, nutrient sensing, immune response, and autophagy in the registered effect.
AB - Aging is one of the global challenges of our time. The search for new anti-aging interventions is also an issue of great actuality. We report on the success of Drosophila melanogaster lifespan extension under the combined influence of dietary restriction, co-administration of berberine, fucoxanthin, and rapamycin, photodeprivation, and low-temperature conditions up to 185 days in w1118 strain and up to 213 days in long-lived E(z)/w mutants. The trade-off was found between longevity and locomotion. The transcriptome analysis showed an impact of epigenetic alterations, lipid metabolism, cellular respiration, nutrient sensing, immune response, and autophagy in the registered effect.
KW - Aging/physiology
KW - Animals
KW - Autophagy
KW - Drosophila melanogaster/genetics
KW - Genotype
KW - Longevity/genetics
UR - http://www.scopus.com/inward/record.url?scp=85131708525&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/18b87e76-2ee1-3327-b58d-1ccc5605cdb0/
U2 - 10.1038/s42003-022-03524-4
DO - 10.1038/s42003-022-03524-4
M3 - Article
C2 - 35681084
AN - SCOPUS:85131708525
VL - 5
JO - Communications Biology
JF - Communications Biology
SN - 2399-3642
IS - 1
M1 - 566
ER -
ID: 36564837