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Molecular mechanisms of exceptional lifespan increase of Drosophila melanogaster with different genotypes after combinations of pro-longevity interventions. / Shaposhnikov, Mikhail V.; Guvatova, Zulfiya G.; Zemskaya, Nadezhda V. et al.

In: Communications Biology, Vol. 5, No. 1, 566, 12.2022.

Research output: Contribution to journal › Article › peer-review

Harvard

Shaposhnikov, MV, Guvatova, ZG, Zemskaya, NV, Koval, LA, Schegoleva, EV, Gorbunova, AA, Golubev, DA, Pakshina, NR, Ulyasheva, NS, Solovev, IA, Bobrovskikh, MA, Gruntenko, NE, Menshanov, PN, Krasnov, GS, Kudryavseva, AV & Moskalev, AA 2022, 'Molecular mechanisms of exceptional lifespan increase of Drosophila melanogaster with different genotypes after combinations of pro-longevity interventions', Communications Biology, vol. 5, no. 1, 566. https://doi.org/10.1038/s42003-022-03524-4

APA

Shaposhnikov, M. V., Guvatova, Z. G., Zemskaya, N. V., Koval, L. A., Schegoleva, E. V., Gorbunova, A. A., Golubev, D. A., Pakshina, N. R., Ulyasheva, N. S., Solovev, I. A., Bobrovskikh, M. A., Gruntenko, N. E., Menshanov, P. N., Krasnov, G. S., Kudryavseva, A. V., & Moskalev, A. A. (2022). Molecular mechanisms of exceptional lifespan increase of Drosophila melanogaster with different genotypes after combinations of pro-longevity interventions. Communications Biology, 5(1), [566]. https://doi.org/10.1038/s42003-022-03524-4

Vancouver

Shaposhnikov MV, Guvatova ZG, Zemskaya NV, Koval LA, Schegoleva EV, Gorbunova AA et al. Molecular mechanisms of exceptional lifespan increase of Drosophila melanogaster with different genotypes after combinations of pro-longevity interventions. Communications Biology. 2022 Dec;5(1):566. doi: 10.1038/s42003-022-03524-4

Author

Shaposhnikov, Mikhail V. ; Guvatova, Zulfiya G. ; Zemskaya, Nadezhda V. et al. / Molecular mechanisms of exceptional lifespan increase of Drosophila melanogaster with different genotypes after combinations of pro-longevity interventions. In: Communications Biology. 2022 ; Vol. 5, No. 1.

BibTeX

@article{959a61330ea940aca8a465a87220c626,
title = "Molecular mechanisms of exceptional lifespan increase of Drosophila melanogaster with different genotypes after combinations of pro-longevity interventions",
abstract = "Aging is one of the global challenges of our time. The search for new anti-aging interventions is also an issue of great actuality. We report on the success of Drosophila melanogaster lifespan extension under the combined influence of dietary restriction, co-administration of berberine, fucoxanthin, and rapamycin, photodeprivation, and low-temperature conditions up to 185 days in w1118 strain and up to 213 days in long-lived E(z)/w mutants. The trade-off was found between longevity and locomotion. The transcriptome analysis showed an impact of epigenetic alterations, lipid metabolism, cellular respiration, nutrient sensing, immune response, and autophagy in the registered effect.",
keywords = "Aging/physiology, Animals, Autophagy, Drosophila melanogaster/genetics, Genotype, Longevity/genetics",
author = "Shaposhnikov, {Mikhail V.} and Guvatova, {Zulfiya G.} and Zemskaya, {Nadezhda V.} and Koval, {Liubov A.} and Schegoleva, {Eugenia V.} and Gorbunova, {Anastasia A.} and Golubev, {Denis A.} and Pakshina, {Natalya R.} and Ulyasheva, {Natalia S.} and Solovev, {Ilya A.} and Bobrovskikh, {Margarita A.} and Gruntenko, {Nataly E.} and Menshanov, {Petr N.} and Krasnov, {George S.} and Kudryavseva, {Anna V.} and Moskalev, {Alexey A.}",
note = "Funding Information: We thank the Center for Precision Genome Editing and Genetic Technologies for Biomedicine, EIMB RAS for providing the computing power and sequencing data analysis. The sequencing was performed using the equipment of EIMB RAS “Genome” center (http://www.eimb.ru/ru1/ckp/ccu_genome_c.php ). The authors would like to thank Nicolay Sidorov for his assistance in purchasing of research reagents at the initial stage of the project. The study was carried out within the framework of the state task on themes “Genetic and functional studies of the effects of geroprotective interventions on the Drosophila melanogaster model”, N 122040600022-1. The analyses of total lipids content were performed by N.E.G, M.A.B. & P.N.M. with support from #FWNR-2022-0019 MSHE project. Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
month = dec,
doi = "10.1038/s42003-022-03524-4",
language = "English",
volume = "5",
journal = "Communications Biology",
issn = "2399-3642",
publisher = "Springer Nature",
number = "1",

}

RIS

TY - JOUR

T1 - Molecular mechanisms of exceptional lifespan increase of Drosophila melanogaster with different genotypes after combinations of pro-longevity interventions

AU - Shaposhnikov, Mikhail V.

AU - Guvatova, Zulfiya G.

AU - Zemskaya, Nadezhda V.

AU - Koval, Liubov A.

AU - Schegoleva, Eugenia V.

AU - Gorbunova, Anastasia A.

AU - Golubev, Denis A.

AU - Pakshina, Natalya R.

AU - Ulyasheva, Natalia S.

AU - Solovev, Ilya A.

AU - Bobrovskikh, Margarita A.

AU - Gruntenko, Nataly E.

AU - Menshanov, Petr N.

AU - Krasnov, George S.

AU - Kudryavseva, Anna V.

AU - Moskalev, Alexey A.

N1 - Funding Information: We thank the Center for Precision Genome Editing and Genetic Technologies for Biomedicine, EIMB RAS for providing the computing power and sequencing data analysis. The sequencing was performed using the equipment of EIMB RAS “Genome” center (http://www.eimb.ru/ru1/ckp/ccu_genome_c.php ). The authors would like to thank Nicolay Sidorov for his assistance in purchasing of research reagents at the initial stage of the project. The study was carried out within the framework of the state task on themes “Genetic and functional studies of the effects of geroprotective interventions on the Drosophila melanogaster model”, N 122040600022-1. The analyses of total lipids content were performed by N.E.G, M.A.B. & P.N.M. with support from #FWNR-2022-0019 MSHE project. Publisher Copyright: © 2022, The Author(s).

PY - 2022/12

Y1 - 2022/12

N2 - Aging is one of the global challenges of our time. The search for new anti-aging interventions is also an issue of great actuality. We report on the success of Drosophila melanogaster lifespan extension under the combined influence of dietary restriction, co-administration of berberine, fucoxanthin, and rapamycin, photodeprivation, and low-temperature conditions up to 185 days in w1118 strain and up to 213 days in long-lived E(z)/w mutants. The trade-off was found between longevity and locomotion. The transcriptome analysis showed an impact of epigenetic alterations, lipid metabolism, cellular respiration, nutrient sensing, immune response, and autophagy in the registered effect.

AB - Aging is one of the global challenges of our time. The search for new anti-aging interventions is also an issue of great actuality. We report on the success of Drosophila melanogaster lifespan extension under the combined influence of dietary restriction, co-administration of berberine, fucoxanthin, and rapamycin, photodeprivation, and low-temperature conditions up to 185 days in w1118 strain and up to 213 days in long-lived E(z)/w mutants. The trade-off was found between longevity and locomotion. The transcriptome analysis showed an impact of epigenetic alterations, lipid metabolism, cellular respiration, nutrient sensing, immune response, and autophagy in the registered effect.

KW - Aging/physiology

KW - Animals

KW - Autophagy

KW - Drosophila melanogaster/genetics

KW - Genotype

KW - Longevity/genetics

UR - http://www.scopus.com/inward/record.url?scp=85131708525&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/18b87e76-2ee1-3327-b58d-1ccc5605cdb0/

U2 - 10.1038/s42003-022-03524-4

DO - 10.1038/s42003-022-03524-4

M3 - Article

C2 - 35681084

AN - SCOPUS:85131708525

VL - 5

JO - Communications Biology

JF - Communications Biology

SN - 2399-3642

IS - 1

M1 - 566

ER -

ID: 36564837