TY - JOUR

T1 - Modified biomimetic core-shell nanostructures enable long circulation and targeted delivery for cancer therapy

AU - Zhang, Yifan

AU - Benassi, Enrico

AU - Shi, Yue

AU - Yue, Xuanyu

AU - Cui, Lin

AU - Yang, Shengchao

AU - Liu, Zhiyong

AU - Guo, Xuhong

N1 - Funding Information: The authors acknowledge financial support from the Corps Division Development and Innovation Support Program (2017BA041), the Corps Division Scientific and Technological Project (2018AB025), the National Natural Science Foundation of China (21866028, 82060646), the Engineering Research Center of Materials-Oriented Chemical Engineering of Xinjiang Bintuan (2016BTRC008, 2016BTRC005), the Natural Science Foundation of Shihezi University (ZZZC201922A, RCZK201914) and the Regional Innovation Guidance Program (2021BB033). Publisher Copyright: © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.

PY - 2021/12/7

Y1 - 2021/12/7

N2 - Significant progress has been made in the application of nanoparticle drug carriers in the treatment of cancer. However, the clearance of nanoparticles by the reticuloendothelial system limits their circulation time and tumor cell targeting, reducing the effectiveness of drug delivery. Herein, we construct a bionic core-shell nanostructure by using a "Trojan horse"strategy. The constructed biotin (bio)-modified red blood cell membrane (RBCm)-coated mesoporous silica nanoparticle (MSN) drug carrier (Bio-RBCm@MSN-DOX) exhibits excellent stability, high efficiency of drug encapsulation, and resistance to elimination by immune cells. Therefore, Bio-RBCm@MSN-DOX is a sustained drug delivery system (SDDS) that prolongs circulation and enhances the effective drug release time. The ability to target HeLa cells increased about 4.64 times and the phagocytic efficiency of macrophages decreased by 2.55 times. The composite core-shell structure developed here can serve as a multifunctional drug carrier system, which can become a novel candidate for "circulating target-therapy"carriers. This journal is

AB - Significant progress has been made in the application of nanoparticle drug carriers in the treatment of cancer. However, the clearance of nanoparticles by the reticuloendothelial system limits their circulation time and tumor cell targeting, reducing the effectiveness of drug delivery. Herein, we construct a bionic core-shell nanostructure by using a "Trojan horse"strategy. The constructed biotin (bio)-modified red blood cell membrane (RBCm)-coated mesoporous silica nanoparticle (MSN) drug carrier (Bio-RBCm@MSN-DOX) exhibits excellent stability, high efficiency of drug encapsulation, and resistance to elimination by immune cells. Therefore, Bio-RBCm@MSN-DOX is a sustained drug delivery system (SDDS) that prolongs circulation and enhances the effective drug release time. The ability to target HeLa cells increased about 4.64 times and the phagocytic efficiency of macrophages decreased by 2.55 times. The composite core-shell structure developed here can serve as a multifunctional drug carrier system, which can become a novel candidate for "circulating target-therapy"carriers. This journal is

KW - DEPENDENT MULTIVITAMIN TRANSPORTER

KW - RELEASE KINETICS

KW - DRUG

KW - NANOPARTICLES

KW - NANOCARRIERS

KW - MICELLES

UR - http://www.scopus.com/inward/record.url?scp=85120380219&partnerID=8YFLogxK

U2 - 10.1039/d1nj04407a

DO - 10.1039/d1nj04407a

M3 - Article

VL - 45

SP - 21359

EP - 21368

JO - New Journal of Chemistry

JF - New Journal of Chemistry

SN - 1144-0546

IS - 45

ER -