Research output: Contribution to journal › Article › peer-review
Modified biomimetic core-shell nanostructures enable long circulation and targeted delivery for cancer therapy. / Zhang, Yifan; Benassi, Enrico; Shi, Yue et al.
In: New Journal of Chemistry, Vol. 45, No. 45, 07.12.2021, p. 21359-21368.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Modified biomimetic core-shell nanostructures enable long circulation and targeted delivery for cancer therapy
AU - Zhang, Yifan
AU - Benassi, Enrico
AU - Shi, Yue
AU - Yue, Xuanyu
AU - Cui, Lin
AU - Yang, Shengchao
AU - Liu, Zhiyong
AU - Guo, Xuhong
N1 - Funding Information: The authors acknowledge financial support from the Corps Division Development and Innovation Support Program (2017BA041), the Corps Division Scientific and Technological Project (2018AB025), the National Natural Science Foundation of China (21866028, 82060646), the Engineering Research Center of Materials-Oriented Chemical Engineering of Xinjiang Bintuan (2016BTRC008, 2016BTRC005), the Natural Science Foundation of Shihezi University (ZZZC201922A, RCZK201914) and the Regional Innovation Guidance Program (2021BB033). Publisher Copyright: © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.
PY - 2021/12/7
Y1 - 2021/12/7
N2 - Significant progress has been made in the application of nanoparticle drug carriers in the treatment of cancer. However, the clearance of nanoparticles by the reticuloendothelial system limits their circulation time and tumor cell targeting, reducing the effectiveness of drug delivery. Herein, we construct a bionic core-shell nanostructure by using a "Trojan horse"strategy. The constructed biotin (bio)-modified red blood cell membrane (RBCm)-coated mesoporous silica nanoparticle (MSN) drug carrier (Bio-RBCm@MSN-DOX) exhibits excellent stability, high efficiency of drug encapsulation, and resistance to elimination by immune cells. Therefore, Bio-RBCm@MSN-DOX is a sustained drug delivery system (SDDS) that prolongs circulation and enhances the effective drug release time. The ability to target HeLa cells increased about 4.64 times and the phagocytic efficiency of macrophages decreased by 2.55 times. The composite core-shell structure developed here can serve as a multifunctional drug carrier system, which can become a novel candidate for "circulating target-therapy"carriers. This journal is
AB - Significant progress has been made in the application of nanoparticle drug carriers in the treatment of cancer. However, the clearance of nanoparticles by the reticuloendothelial system limits their circulation time and tumor cell targeting, reducing the effectiveness of drug delivery. Herein, we construct a bionic core-shell nanostructure by using a "Trojan horse"strategy. The constructed biotin (bio)-modified red blood cell membrane (RBCm)-coated mesoporous silica nanoparticle (MSN) drug carrier (Bio-RBCm@MSN-DOX) exhibits excellent stability, high efficiency of drug encapsulation, and resistance to elimination by immune cells. Therefore, Bio-RBCm@MSN-DOX is a sustained drug delivery system (SDDS) that prolongs circulation and enhances the effective drug release time. The ability to target HeLa cells increased about 4.64 times and the phagocytic efficiency of macrophages decreased by 2.55 times. The composite core-shell structure developed here can serve as a multifunctional drug carrier system, which can become a novel candidate for "circulating target-therapy"carriers. This journal is
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UR - http://www.scopus.com/inward/record.url?scp=85120380219&partnerID=8YFLogxK
U2 - 10.1039/d1nj04407a
DO - 10.1039/d1nj04407a
M3 - Article
VL - 45
SP - 21359
EP - 21368
JO - New Journal of Chemistry
JF - New Journal of Chemistry
SN - 1144-0546
IS - 45
ER -
ID: 34689518