TY - JOUR

T1 - Modeling the drug withdrawal syndrome in zebrafish (Danio rerio)

AU - Zabegalov, Konstantin N.

AU - Galstyan, David S.

AU - Kolesnikova, Tatyana O.

AU - Kositsyn, Yurii M.

AU - Gubaidullina, Mariya A.

AU - Maslov, Gleb O.

AU - Demin, Konstantin A.

AU - Khatsko, Sergey L.

AU - Kalueff, Allan V.

N1 - Публикация на корректировке.

PY - 2022

Y1 - 2022

N2 - The central pathological link in addictive states is the drug withdrawal syndrome. Usually, severe manifestations of the withdrawal syndrome are associated with reduced sensitivity of postsynaptic receptors (desensitization), lower den-sity of receptors and impaired transport of neurotransmitters, and the rebound effect. Zebrafish is an effective tool in the study of classic withdrawal symptoms and special cases of withdrawal of other selected psychoactive drugs.

AB - The central pathological link in addictive states is the drug withdrawal syndrome. Usually, severe manifestations of the withdrawal syndrome are associated with reduced sensitivity of postsynaptic receptors (desensitization), lower den-sity of receptors and impaired transport of neurotransmitters, and the rebound effect. Zebrafish is an effective tool in the study of classic withdrawal symptoms and special cases of withdrawal of other selected psychoactive drugs.

KW - addiction

KW - ethanol

KW - morphine

KW - withdrawal syndrome

KW - zebrafish

UR - https://www.mendeley.com/catalogue/211aa837-37d4-31d7-b049-b6a30354ba32/

U2 - 10.17816/RCF202185-191

DO - 10.17816/RCF202185-191

M3 - Article

VL - 20

SP - 185

EP - 191

JO - Reviews on Clinical Pharmacology and Drug Therapy

JF - Reviews on Clinical Pharmacology and Drug Therapy

SN - 2542-1875

IS - 2

ER -