TY - JOUR

T1 - Modeling and assaying seizure activity in zebrafish (Danio rerio)

AU - Galstyan, David S.

AU - Kolesnikova, Tatyana O.

AU - Kositsyn, Yurii M.

AU - Zabegalov, Konstantin N.

AU - Gubaidullina, Mariya A.

AU - Maslov, Gleb O.

AU - Demin, Konstantin A.

AU - Kalueff, Allan V.

N1 - Публикация для корректировки.

PY - 2022

Y1 - 2022

N2 - Epilepsy is a common neurological disease that has many causes with unclear pathophysiological mechanisms. Epilepsy, commonly studied in rodents, can also be modeled in zebrafish (Danio rerio). There are effective pharmacological and genetic models for zebrafish, sensitive to both pro and anticonvulsant effects. These aquatic models are likely to help expand the fundamental knowledge about the mechanisms of epilepsy pathogenesis and develop epilepsy therapy.

AB - Epilepsy is a common neurological disease that has many causes with unclear pathophysiological mechanisms. Epilepsy, commonly studied in rodents, can also be modeled in zebrafish (Danio rerio). There are effective pharmacological and genetic models for zebrafish, sensitive to both pro and anticonvulsant effects. These aquatic models are likely to help expand the fundamental knowledge about the mechanisms of epilepsy pathogenesis and develop epilepsy therapy.

KW - epilepsy

KW - hyperactivity

KW - seizures

KW - strychnine

KW - zebrafish

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85166744597&origin=inward&txGid=b53390a51c4550330453ed8345b9ce2a

UR - https://www.mendeley.com/catalogue/32c8a549-4a4f-3e2a-8201-4d6334553840/

U2 - 10.17816/RCF202193-199

DO - 10.17816/RCF202193-199

M3 - Article

VL - 20

SP - 193

EP - 199

JO - Reviews on Clinical Pharmacology and Drug Therapy

JF - Reviews on Clinical Pharmacology and Drug Therapy

SN - 2542-1875

IS - 2

ER -