Modeling and assaying seizure activity in zebrafish (Danio rerio). / Galstyan, David S.; Kolesnikova, Tatyana O.; Kositsyn, Yurii M. et al.
In: Reviews on Clinical Pharmacology and Drug Therapy, Vol. 20, No. 2, 2022, p. 193-199.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Modeling and assaying seizure activity in zebrafish (Danio rerio)
AU - Galstyan, David S.
AU - Kolesnikova, Tatyana O.
AU - Kositsyn, Yurii M.
AU - Zabegalov, Konstantin N.
AU - Gubaidullina, Mariya A.
AU - Maslov, Gleb O.
AU - Demin, Konstantin A.
AU - Kalueff, Allan V.
N1 - Публикация для корректировки.
PY - 2022
Y1 - 2022
N2 - Epilepsy is a common neurological disease that has many causes with unclear pathophysiological mechanisms. Epilepsy, commonly studied in rodents, can also be modeled in zebrafish (Danio rerio). There are effective pharmacological and genetic models for zebrafish, sensitive to both pro and anticonvulsant effects. These aquatic models are likely to help expand the fundamental knowledge about the mechanisms of epilepsy pathogenesis and develop epilepsy therapy.
AB - Epilepsy is a common neurological disease that has many causes with unclear pathophysiological mechanisms. Epilepsy, commonly studied in rodents, can also be modeled in zebrafish (Danio rerio). There are effective pharmacological and genetic models for zebrafish, sensitive to both pro and anticonvulsant effects. These aquatic models are likely to help expand the fundamental knowledge about the mechanisms of epilepsy pathogenesis and develop epilepsy therapy.
KW - epilepsy
KW - hyperactivity
KW - seizures
KW - strychnine
KW - zebrafish
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85166744597&origin=inward&txGid=b53390a51c4550330453ed8345b9ce2a
UR - https://www.mendeley.com/catalogue/32c8a549-4a4f-3e2a-8201-4d6334553840/
U2 - 10.17816/RCF202193-199
DO - 10.17816/RCF202193-199
M3 - Article
VL - 20
SP - 193
EP - 199
JO - Reviews on Clinical Pharmacology and Drug Therapy
JF - Reviews on Clinical Pharmacology and Drug Therapy
SN - 2542-1875
IS - 2
ER -
ID: 55722014