TY - JOUR

T1 - Major Scenarios of Genetically Regulated Cell Death during Oogenesis in Drosophila melanogaster

AU - Bolobolova, E. U.

AU - Dorogova, N. V.

AU - Fedorova, S. A.

PY - 2020/6/1

Y1 - 2020/6/1

N2 - The process of regulated cell death (RCD), as well as proliferation and differentiation, is an important and integral part of the development of any multicellular organism. There are a number of different mechanisms of RCD that can be activated in response to developmental and environmental signals. In this review, we focus on the new insights into the main cellular events and molecular mechanisms characterizing different cell death pathways during oogenesis in Drosophila melanogaster. During Drosophila oogenesis, at least five different stage-specific RCD scenarios are realized, including (1) caspase-dependent death of the germline cells (GCs) in early oogenesis, which is mediated by autophagy; (2) canonical apoptosis, which removes the excess of somatic polar cells at stages 4–5 of oogenesis; (3) RCD of mid-stage egg chambers, which begins with caspase-dependent death of GCs with the participation of autophagy and finishes with their engulfment by the surrounding follicle cells (FCs); (4) non-apoptotic RCD of late-stage nurse cells, initiated and controlled by the surrounding FCs; (5) caspase-independent death of the FCs that have fulfilled their functions through autophagy at the end of stage 14.

AB - The process of regulated cell death (RCD), as well as proliferation and differentiation, is an important and integral part of the development of any multicellular organism. There are a number of different mechanisms of RCD that can be activated in response to developmental and environmental signals. In this review, we focus on the new insights into the main cellular events and molecular mechanisms characterizing different cell death pathways during oogenesis in Drosophila melanogaster. During Drosophila oogenesis, at least five different stage-specific RCD scenarios are realized, including (1) caspase-dependent death of the germline cells (GCs) in early oogenesis, which is mediated by autophagy; (2) canonical apoptosis, which removes the excess of somatic polar cells at stages 4–5 of oogenesis; (3) RCD of mid-stage egg chambers, which begins with caspase-dependent death of GCs with the participation of autophagy and finishes with their engulfment by the surrounding follicle cells (FCs); (4) non-apoptotic RCD of late-stage nurse cells, initiated and controlled by the surrounding FCs; (5) caspase-independent death of the FCs that have fulfilled their functions through autophagy at the end of stage 14.

KW - apoptosis

KW - autophagy

KW - Drosophila

KW - oogenesis

KW - regulated cell death

KW - STEM-CELLS

KW - PHAGOCYTOSIS

KW - EFFECTOR CASPASE DCP-1

KW - OVARIAN DEVELOPMENT

KW - MECHANISMS

KW - FOLLICLE CELLS

KW - DROSOPHILA

KW - MITOCHONDRIAL DYNAMICS

KW - APOPTOTIC CELLS

KW - NURSE CELLS

UR - http://www.scopus.com/inward/record.url?scp=85087449127&partnerID=8YFLogxK

U2 - 10.1134/S1022795420060034

DO - 10.1134/S1022795420060034

M3 - Article

AN - SCOPUS:85087449127

VL - 56

SP - 655

EP - 665

JO - Russian Journal of Genetics

JF - Russian Journal of Genetics

SN - 1022-7954

IS - 6

ER -