Research output: Contribution to journal › Article › peer-review
Major Scenarios of Genetically Regulated Cell Death during Oogenesis in Drosophila melanogaster. / Bolobolova, E. U.; Dorogova, N. V.; Fedorova, S. A.
In: Russian Journal of Genetics, Vol. 56, No. 6, 01.06.2020, p. 655-665.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Major Scenarios of Genetically Regulated Cell Death during Oogenesis in Drosophila melanogaster
AU - Bolobolova, E. U.
AU - Dorogova, N. V.
AU - Fedorova, S. A.
PY - 2020/6/1
Y1 - 2020/6/1
N2 - The process of regulated cell death (RCD), as well as proliferation and differentiation, is an important and integral part of the development of any multicellular organism. There are a number of different mechanisms of RCD that can be activated in response to developmental and environmental signals. In this review, we focus on the new insights into the main cellular events and molecular mechanisms characterizing different cell death pathways during oogenesis in Drosophila melanogaster. During Drosophila oogenesis, at least five different stage-specific RCD scenarios are realized, including (1) caspase-dependent death of the germline cells (GCs) in early oogenesis, which is mediated by autophagy; (2) canonical apoptosis, which removes the excess of somatic polar cells at stages 4–5 of oogenesis; (3) RCD of mid-stage egg chambers, which begins with caspase-dependent death of GCs with the participation of autophagy and finishes with their engulfment by the surrounding follicle cells (FCs); (4) non-apoptotic RCD of late-stage nurse cells, initiated and controlled by the surrounding FCs; (5) caspase-independent death of the FCs that have fulfilled their functions through autophagy at the end of stage 14.
AB - The process of regulated cell death (RCD), as well as proliferation and differentiation, is an important and integral part of the development of any multicellular organism. There are a number of different mechanisms of RCD that can be activated in response to developmental and environmental signals. In this review, we focus on the new insights into the main cellular events and molecular mechanisms characterizing different cell death pathways during oogenesis in Drosophila melanogaster. During Drosophila oogenesis, at least five different stage-specific RCD scenarios are realized, including (1) caspase-dependent death of the germline cells (GCs) in early oogenesis, which is mediated by autophagy; (2) canonical apoptosis, which removes the excess of somatic polar cells at stages 4–5 of oogenesis; (3) RCD of mid-stage egg chambers, which begins with caspase-dependent death of GCs with the participation of autophagy and finishes with their engulfment by the surrounding follicle cells (FCs); (4) non-apoptotic RCD of late-stage nurse cells, initiated and controlled by the surrounding FCs; (5) caspase-independent death of the FCs that have fulfilled their functions through autophagy at the end of stage 14.
KW - apoptosis
KW - autophagy
KW - Drosophila
KW - oogenesis
KW - regulated cell death
KW - STEM-CELLS
KW - PHAGOCYTOSIS
KW - EFFECTOR CASPASE DCP-1
KW - OVARIAN DEVELOPMENT
KW - MECHANISMS
KW - FOLLICLE CELLS
KW - DROSOPHILA
KW - MITOCHONDRIAL DYNAMICS
KW - APOPTOTIC CELLS
KW - NURSE CELLS
UR - http://www.scopus.com/inward/record.url?scp=85087449127&partnerID=8YFLogxK
U2 - 10.1134/S1022795420060034
DO - 10.1134/S1022795420060034
M3 - Article
AN - SCOPUS:85087449127
VL - 56
SP - 655
EP - 665
JO - Russian Journal of Genetics
JF - Russian Journal of Genetics
SN - 1022-7954
IS - 6
ER -
ID: 24722179