Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Lipophilic Metabolites from Five-Needle Pines, Pinus armandii and Pinus kwangtungensis, Exhibiting Antibacterial Activity. / Shpatov, Alexander V.; Frolova, Tatyana S.; Popov, Sergey A. и др.
в: Chemistry and Biodiversity, Том 17, № 8, e2000201, 01.08.2020.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Lipophilic Metabolites from Five-Needle Pines, Pinus armandii and Pinus kwangtungensis, Exhibiting Antibacterial Activity
AU - Shpatov, Alexander V.
AU - Frolova, Tatyana S.
AU - Popov, Sergey A.
AU - Sinitsyna, Olga I.
AU - Salnikova, Olga I.
AU - Zheng, Guangyao
AU - Yan, Linlin
AU - Sinelnikova, Nadezhda V.
AU - Pshennikova, Lyudmila M.
AU - Kochetov, Alexey V.
N1 - Publisher Copyright: © 2020 Wiley-VHCA AG, Zurich, Switzerland Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/8/1
Y1 - 2020/8/1
N2 - Lipophilic extractive metabolites from needles and defoliated twigs of Pinus armandii and P. kwangtungensis were studied by GC/MS. Needles of P. armandii contained predominantly 15-O-functionalized labdane type acids (anticopalic acid), fatty acids, nonacosan-10-ol, sterols, nonacosan-10-ol and sterol saponifiable esters, and acylglycerols, while P. kwangtungensis needles contained no anticopalic acid, but more trinorlabdane (14,15,16-trinor-8(17)-labdene-13,19-dioic acid) and other labdane type acids, nonacosan-10-ol and its saponifiable esters. The major compounds in the P. armandii defoliated twig extract were abietane and isopimarane type acids, fatty acids, sterols, labdanoids (cis-abienol), cembranoids (isocembrol and 4-epi-isocembrol), saponifiable sterol esters, and acylglycerols. The same extract of P. kwangtungensis contained larger quantities of fatty acids, caryophyllene oxide, serratanoids, sterols, saponifiable sterol esters, and acylglycerols, but lesser amounts of abietane and isopimarane type acids, cis-abienol, and lacked cembranoids. Both twig and needle extracts of P. armandii and P. kwangtungensis, as well as the extracts’ fractions, significantly inhibited the growth of Gram-negative bacteria Serratia marcescens with MIC of 0.1 mg ml−1, while in most cases they slightly stimulated the growth of Gram-positive bacteria Bacillus subtilis at the same concentrations. Thus, lipophilic extractive compounds from the needles and defoliated twigs of both pines are prospective for the development of antiseptics against Gram-negative bacteria.
AB - Lipophilic extractive metabolites from needles and defoliated twigs of Pinus armandii and P. kwangtungensis were studied by GC/MS. Needles of P. armandii contained predominantly 15-O-functionalized labdane type acids (anticopalic acid), fatty acids, nonacosan-10-ol, sterols, nonacosan-10-ol and sterol saponifiable esters, and acylglycerols, while P. kwangtungensis needles contained no anticopalic acid, but more trinorlabdane (14,15,16-trinor-8(17)-labdene-13,19-dioic acid) and other labdane type acids, nonacosan-10-ol and its saponifiable esters. The major compounds in the P. armandii defoliated twig extract were abietane and isopimarane type acids, fatty acids, sterols, labdanoids (cis-abienol), cembranoids (isocembrol and 4-epi-isocembrol), saponifiable sterol esters, and acylglycerols. The same extract of P. kwangtungensis contained larger quantities of fatty acids, caryophyllene oxide, serratanoids, sterols, saponifiable sterol esters, and acylglycerols, but lesser amounts of abietane and isopimarane type acids, cis-abienol, and lacked cembranoids. Both twig and needle extracts of P. armandii and P. kwangtungensis, as well as the extracts’ fractions, significantly inhibited the growth of Gram-negative bacteria Serratia marcescens with MIC of 0.1 mg ml−1, while in most cases they slightly stimulated the growth of Gram-positive bacteria Bacillus subtilis at the same concentrations. Thus, lipophilic extractive compounds from the needles and defoliated twigs of both pines are prospective for the development of antiseptics against Gram-negative bacteria.
KW - antibacterial activity
KW - Bacillus subtilis
KW - GC/MS
KW - Pinus armandii
KW - Pinus kwangtungensis
KW - Serratia marcescens
KW - MS
KW - ESSENTIAL OIL
KW - COMPONENTS
KW - PINE-CONES
KW - NEEDLES
KW - DITERPENOIDS
KW - ANTIOXIDANT
KW - CHEMICAL-COMPOSITION
KW - GC
KW - ANTIMICROBIAL ACTIVITY
KW - EXTRACT
KW - CONSTITUENTS
UR - http://www.scopus.com/inward/record.url?scp=85087508083&partnerID=8YFLogxK
U2 - 10.1002/cbdv.202000201
DO - 10.1002/cbdv.202000201
M3 - Article
C2 - 32413199
AN - SCOPUS:85087508083
VL - 17
JO - Chemistry and Biodiversity
JF - Chemistry and Biodiversity
SN - 1612-1872
IS - 8
M1 - e2000201
ER -
ID: 24719252