Lipophilic Metabolites from Five-Needle Pines, Pinus armandii and Pinus kwangtungensis, Exhibiting Antibacterial Activity

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Lipophilic Metabolites from Five-Needle Pines, Pinus armandii and Pinus kwangtungensis, Exhibiting Antibacterial Activity. / Shpatov, Alexander V.; Frolova, Tatyana S.; Popov, Sergey A. et al.

In: Chemistry and Biodiversity, Vol. 17, No. 8, e2000201, 01.08.2020.

Research output: Contribution to journal › Article › peer-review

Harvard

Shpatov, AV, Frolova, TS, Popov, SA, Sinitsyna, OI, Salnikova, OI, Zheng, G, Yan, L, Sinelnikova, NV, Pshennikova, LM & Kochetov, AV 2020, 'Lipophilic Metabolites from Five-Needle Pines, Pinus armandii and Pinus kwangtungensis, Exhibiting Antibacterial Activity', Chemistry and Biodiversity, vol. 17, no. 8, e2000201. https://doi.org/10.1002/cbdv.202000201

APA

Shpatov, A. V., Frolova, T. S., Popov, S. A., Sinitsyna, O. I., Salnikova, O. I., Zheng, G., Yan, L., Sinelnikova, N. V., Pshennikova, L. M., & Kochetov, A. V. (2020). Lipophilic Metabolites from Five-Needle Pines, Pinus armandii and Pinus kwangtungensis, Exhibiting Antibacterial Activity. Chemistry and Biodiversity, 17(8), [e2000201]. https://doi.org/10.1002/cbdv.202000201

Vancouver

Shpatov AV, Frolova TS, Popov SA, Sinitsyna OI, Salnikova OI, Zheng G et al. Lipophilic Metabolites from Five-Needle Pines, Pinus armandii and Pinus kwangtungensis, Exhibiting Antibacterial Activity. Chemistry and Biodiversity. 2020 Aug 1;17(8):e2000201. Epub 2020 Jul 3. doi: 10.1002/cbdv.202000201

Author

Shpatov, Alexander V. ; Frolova, Tatyana S. ; Popov, Sergey A. et al. / Lipophilic Metabolites from Five-Needle Pines, Pinus armandii and Pinus kwangtungensis, Exhibiting Antibacterial Activity. In: Chemistry and Biodiversity. 2020 ; Vol. 17, No. 8.

BibTeX

@article{e2388b0ce2304d38bb47b37f364b4731,

title = "Lipophilic Metabolites from Five-Needle Pines, Pinus armandii and Pinus kwangtungensis, Exhibiting Antibacterial Activity",

abstract = "Lipophilic extractive metabolites from needles and defoliated twigs of Pinus armandii and P. kwangtungensis were studied by GC/MS. Needles of P. armandii contained predominantly 15-O-functionalized labdane type acids (anticopalic acid), fatty acids, nonacosan-10-ol, sterols, nonacosan-10-ol and sterol saponifiable esters, and acylglycerols, while P. kwangtungensis needles contained no anticopalic acid, but more trinorlabdane (14,15,16-trinor-8(17)-labdene-13,19-dioic acid) and other labdane type acids, nonacosan-10-ol and its saponifiable esters. The major compounds in the P. armandii defoliated twig extract were abietane and isopimarane type acids, fatty acids, sterols, labdanoids (cis-abienol), cembranoids (isocembrol and 4-epi-isocembrol), saponifiable sterol esters, and acylglycerols. The same extract of P. kwangtungensis contained larger quantities of fatty acids, caryophyllene oxide, serratanoids, sterols, saponifiable sterol esters, and acylglycerols, but lesser amounts of abietane and isopimarane type acids, cis-abienol, and lacked cembranoids. Both twig and needle extracts of P. armandii and P. kwangtungensis, as well as the extracts{\textquoteright} fractions, significantly inhibited the growth of Gram-negative bacteria Serratia marcescens with MIC of 0.1 mg ml−1, while in most cases they slightly stimulated the growth of Gram-positive bacteria Bacillus subtilis at the same concentrations. Thus, lipophilic extractive compounds from the needles and defoliated twigs of both pines are prospective for the development of antiseptics against Gram-negative bacteria.",

keywords = "antibacterial activity, Bacillus subtilis, GC/MS, Pinus armandii, Pinus kwangtungensis, Serratia marcescens, MS, ESSENTIAL OIL, COMPONENTS, PINE-CONES, NEEDLES, DITERPENOIDS, ANTIOXIDANT, CHEMICAL-COMPOSITION, GC, ANTIMICROBIAL ACTIVITY, EXTRACT, CONSTITUENTS",

author = "Shpatov, {Alexander V.} and Frolova, {Tatyana S.} and Popov, {Sergey A.} and Sinitsyna, {Olga I.} and Salnikova, {Olga I.} and Guangyao Zheng and Linlin Yan and Sinelnikova, {Nadezhda V.} and Pshennikova, {Lyudmila M.} and Kochetov, {Alexey V.}",

year = "2020",

month = aug,

day = "1",

doi = "10.1002/cbdv.202000201",

language = "English",

volume = "17",

journal = "Chemistry and Biodiversity",

issn = "1612-1872",

publisher = "Wiley-Blackwell",

number = "8",

}

RIS

TY - JOUR

T1 - Lipophilic Metabolites from Five-Needle Pines, Pinus armandii and Pinus kwangtungensis, Exhibiting Antibacterial Activity

AU - Shpatov, Alexander V.

AU - Frolova, Tatyana S.

AU - Popov, Sergey A.

AU - Sinitsyna, Olga I.

AU - Salnikova, Olga I.

AU - Zheng, Guangyao

AU - Yan, Linlin

AU - Sinelnikova, Nadezhda V.

AU - Pshennikova, Lyudmila M.

AU - Kochetov, Alexey V.

PY - 2020/8/1

Y1 - 2020/8/1

N2 - Lipophilic extractive metabolites from needles and defoliated twigs of Pinus armandii and P. kwangtungensis were studied by GC/MS. Needles of P. armandii contained predominantly 15-O-functionalized labdane type acids (anticopalic acid), fatty acids, nonacosan-10-ol, sterols, nonacosan-10-ol and sterol saponifiable esters, and acylglycerols, while P. kwangtungensis needles contained no anticopalic acid, but more trinorlabdane (14,15,16-trinor-8(17)-labdene-13,19-dioic acid) and other labdane type acids, nonacosan-10-ol and its saponifiable esters. The major compounds in the P. armandii defoliated twig extract were abietane and isopimarane type acids, fatty acids, sterols, labdanoids (cis-abienol), cembranoids (isocembrol and 4-epi-isocembrol), saponifiable sterol esters, and acylglycerols. The same extract of P. kwangtungensis contained larger quantities of fatty acids, caryophyllene oxide, serratanoids, sterols, saponifiable sterol esters, and acylglycerols, but lesser amounts of abietane and isopimarane type acids, cis-abienol, and lacked cembranoids. Both twig and needle extracts of P. armandii and P. kwangtungensis, as well as the extracts’ fractions, significantly inhibited the growth of Gram-negative bacteria Serratia marcescens with MIC of 0.1 mg ml−1, while in most cases they slightly stimulated the growth of Gram-positive bacteria Bacillus subtilis at the same concentrations. Thus, lipophilic extractive compounds from the needles and defoliated twigs of both pines are prospective for the development of antiseptics against Gram-negative bacteria.

AB - Lipophilic extractive metabolites from needles and defoliated twigs of Pinus armandii and P. kwangtungensis were studied by GC/MS. Needles of P. armandii contained predominantly 15-O-functionalized labdane type acids (anticopalic acid), fatty acids, nonacosan-10-ol, sterols, nonacosan-10-ol and sterol saponifiable esters, and acylglycerols, while P. kwangtungensis needles contained no anticopalic acid, but more trinorlabdane (14,15,16-trinor-8(17)-labdene-13,19-dioic acid) and other labdane type acids, nonacosan-10-ol and its saponifiable esters. The major compounds in the P. armandii defoliated twig extract were abietane and isopimarane type acids, fatty acids, sterols, labdanoids (cis-abienol), cembranoids (isocembrol and 4-epi-isocembrol), saponifiable sterol esters, and acylglycerols. The same extract of P. kwangtungensis contained larger quantities of fatty acids, caryophyllene oxide, serratanoids, sterols, saponifiable sterol esters, and acylglycerols, but lesser amounts of abietane and isopimarane type acids, cis-abienol, and lacked cembranoids. Both twig and needle extracts of P. armandii and P. kwangtungensis, as well as the extracts’ fractions, significantly inhibited the growth of Gram-negative bacteria Serratia marcescens with MIC of 0.1 mg ml−1, while in most cases they slightly stimulated the growth of Gram-positive bacteria Bacillus subtilis at the same concentrations. Thus, lipophilic extractive compounds from the needles and defoliated twigs of both pines are prospective for the development of antiseptics against Gram-negative bacteria.

KW - antibacterial activity

KW - Bacillus subtilis

KW - GC/MS

KW - Pinus armandii

KW - Pinus kwangtungensis

KW - Serratia marcescens

KW - MS

KW - ESSENTIAL OIL

KW - COMPONENTS

KW - PINE-CONES

KW - NEEDLES

KW - DITERPENOIDS

KW - ANTIOXIDANT

KW - CHEMICAL-COMPOSITION

KW - GC

KW - ANTIMICROBIAL ACTIVITY

KW - EXTRACT

KW - CONSTITUENTS

UR - http://www.scopus.com/inward/record.url?scp=85087508083&partnerID=8YFLogxK

U2 - 10.1002/cbdv.202000201

DO - 10.1002/cbdv.202000201

M3 - Article

C2 - 32413199

AN - SCOPUS:85087508083

VL - 17

JO - Chemistry and Biodiversity

JF - Chemistry and Biodiversity

SN - 1612-1872

IS - 8

M1 - e2000201

ER -

ID: 24719252