TY - JOUR

T1 - Impact of polymorphisms in the serotonin transporter gene on oscillatory dynamics during inhibition of planned movement in children

AU - Bocharov, Andrey V.

AU - Savostyanov, Alexander N.

AU - Tamozhnikov, Sergey S.

AU - Saprigyn, Alexander E.

AU - Proshina, Ekaterina A.

AU - Astakhova, Tatiana N.

AU - Knyazev, Gennady G.

PY - 2019/11/6

Y1 - 2019/11/6

N2 - The serotonin transporter plays an important role in serotonergic neuromodulation. It is known that polymorphisms in the serotonin transporter gene are linked to the dysregulation of emotions. In the current study, we aimed to investigate the impact of variation in the gene encoding serotonin transporter polymorphism on oscillatory dynamics during inhibition of planned movement in the stop signal paradigm. During performance the stop signal paradigm, electroencephalograms (EEGs) were recorded in 90 healthy Caucasian children (39 girls) from 7 to 12 years. Buccal epithelium probes were taken from all participants. The La, Lg, and S alleles of serotonin transporter‐linked polymorphic region (5‐HTTLPR) polymorphism were detected in the DNA samples using PCR. LaLa genotype carriers did not differ from LaS\LgS and LgS\LgLg\SS carriers in a number of successful inhibitions of a prepotent response. Carriers of LaLa exhibit higher alpha and beta event‐related spectral perturbations (ERSP) in parietal and occipital cortices after the presentation of signal of inhibition of movement than LaS\LgS and LgS\LgLg\SS carriers. Results are consistent with current literature and confirm that S allele carriers are more predisposed to disturbances in cognitive control.

AB - The serotonin transporter plays an important role in serotonergic neuromodulation. It is known that polymorphisms in the serotonin transporter gene are linked to the dysregulation of emotions. In the current study, we aimed to investigate the impact of variation in the gene encoding serotonin transporter polymorphism on oscillatory dynamics during inhibition of planned movement in the stop signal paradigm. During performance the stop signal paradigm, electroencephalograms (EEGs) were recorded in 90 healthy Caucasian children (39 girls) from 7 to 12 years. Buccal epithelium probes were taken from all participants. The La, Lg, and S alleles of serotonin transporter‐linked polymorphic region (5‐HTTLPR) polymorphism were detected in the DNA samples using PCR. LaLa genotype carriers did not differ from LaS\LgS and LgS\LgLg\SS carriers in a number of successful inhibitions of a prepotent response. Carriers of LaLa exhibit higher alpha and beta event‐related spectral perturbations (ERSP) in parietal and occipital cortices after the presentation of signal of inhibition of movement than LaS\LgS and LgS\LgLg\SS carriers. Results are consistent with current literature and confirm that S allele carriers are more predisposed to disturbances in cognitive control.

KW - Alpha oscillations

KW - Beta oscillations

KW - Inhibition

KW - Serotonin transporter polymorphism

KW - Stop signal paradigm

KW - DEPRESSION

KW - ANXIETY

KW - beta oscillations

KW - inhibition

KW - RISK

KW - alpha oscillations

KW - stop signal paradigm

KW - serotonin transporter polymorphism

KW - TRYPTOPHAN DEPLETION

KW - INDIVIDUAL-DIFFERENCES

KW - RESPONSE-INHIBITION

KW - 5-HTTLPR GENOTYPE

KW - MOTOR

KW - STRESS

KW - ASSOCIATION

UR - http://www.scopus.com/inward/record.url?scp=85074649655&partnerID=8YFLogxK

U2 - 10.3390/brainsci9110311

DO - 10.3390/brainsci9110311

M3 - Article

C2 - 31698879

AN - SCOPUS:85074649655

VL - 9

JO - Brain Sciences

JF - Brain Sciences

SN - 2076-3425

IS - 11

M1 - 311

ER -