Research output: Contribution to journal › Article › peer-review
Impact of polymorphisms in the serotonin transporter gene on oscillatory dynamics during inhibition of planned movement in children. / Bocharov, Andrey V.; Savostyanov, Alexander N.; Tamozhnikov, Sergey S. et al.
In: Brain Sciences, Vol. 9, No. 11, 311, 06.11.2019.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Impact of polymorphisms in the serotonin transporter gene on oscillatory dynamics during inhibition of planned movement in children
AU - Bocharov, Andrey V.
AU - Savostyanov, Alexander N.
AU - Tamozhnikov, Sergey S.
AU - Saprigyn, Alexander E.
AU - Proshina, Ekaterina A.
AU - Astakhova, Tatiana N.
AU - Knyazev, Gennady G.
PY - 2019/11/6
Y1 - 2019/11/6
N2 - The serotonin transporter plays an important role in serotonergic neuromodulation. It is known that polymorphisms in the serotonin transporter gene are linked to the dysregulation of emotions. In the current study, we aimed to investigate the impact of variation in the gene encoding serotonin transporter polymorphism on oscillatory dynamics during inhibition of planned movement in the stop signal paradigm. During performance the stop signal paradigm, electroencephalograms (EEGs) were recorded in 90 healthy Caucasian children (39 girls) from 7 to 12 years. Buccal epithelium probes were taken from all participants. The La, Lg, and S alleles of serotonin transporter‐linked polymorphic region (5‐HTTLPR) polymorphism were detected in the DNA samples using PCR. LaLa genotype carriers did not differ from LaS\LgS and LgS\LgLg\SS carriers in a number of successful inhibitions of a prepotent response. Carriers of LaLa exhibit higher alpha and beta event‐related spectral perturbations (ERSP) in parietal and occipital cortices after the presentation of signal of inhibition of movement than LaS\LgS and LgS\LgLg\SS carriers. Results are consistent with current literature and confirm that S allele carriers are more predisposed to disturbances in cognitive control.
AB - The serotonin transporter plays an important role in serotonergic neuromodulation. It is known that polymorphisms in the serotonin transporter gene are linked to the dysregulation of emotions. In the current study, we aimed to investigate the impact of variation in the gene encoding serotonin transporter polymorphism on oscillatory dynamics during inhibition of planned movement in the stop signal paradigm. During performance the stop signal paradigm, electroencephalograms (EEGs) were recorded in 90 healthy Caucasian children (39 girls) from 7 to 12 years. Buccal epithelium probes were taken from all participants. The La, Lg, and S alleles of serotonin transporter‐linked polymorphic region (5‐HTTLPR) polymorphism were detected in the DNA samples using PCR. LaLa genotype carriers did not differ from LaS\LgS and LgS\LgLg\SS carriers in a number of successful inhibitions of a prepotent response. Carriers of LaLa exhibit higher alpha and beta event‐related spectral perturbations (ERSP) in parietal and occipital cortices after the presentation of signal of inhibition of movement than LaS\LgS and LgS\LgLg\SS carriers. Results are consistent with current literature and confirm that S allele carriers are more predisposed to disturbances in cognitive control.
KW - Alpha oscillations
KW - Beta oscillations
KW - Inhibition
KW - Serotonin transporter polymorphism
KW - Stop signal paradigm
KW - DEPRESSION
KW - ANXIETY
KW - beta oscillations
KW - inhibition
KW - RISK
KW - alpha oscillations
KW - stop signal paradigm
KW - serotonin transporter polymorphism
KW - TRYPTOPHAN DEPLETION
KW - INDIVIDUAL-DIFFERENCES
KW - RESPONSE-INHIBITION
KW - 5-HTTLPR GENOTYPE
KW - MOTOR
KW - STRESS
KW - ASSOCIATION
UR - http://www.scopus.com/inward/record.url?scp=85074649655&partnerID=8YFLogxK
U2 - 10.3390/brainsci9110311
DO - 10.3390/brainsci9110311
M3 - Article
C2 - 31698879
AN - SCOPUS:85074649655
VL - 9
JO - Brain Sciences
JF - Brain Sciences
SN - 2076-3425
IS - 11
M1 - 311
ER -
ID: 22333737