TY - JOUR

T1 - How miRNA Structure of Animals Influences Their Biogenesis

AU - Vorozheykin, P. S.

AU - Titov, I. I.

N1 - Publisher Copyright: © 2020, Pleiades Publishing, Inc.

PY - 2020/1

Y1 - 2020/1

N2 - MicroRNAs are small noncoding RNAs that are involved in the post-transcriptional regulation of the gene expression in various organisms. This article reviews recent advances in understanding the role of the primary and secondary structures of animal miRNA precursors through the biogenesis stages and the miRNA maturation steps. Also, we describe the effects of genetic variability and heterogeneity of miRNA ends, which play an important role in epitranscriptomics as well as annotation errors in the miRNA databases.

AB - MicroRNAs are small noncoding RNAs that are involved in the post-transcriptional regulation of the gene expression in various organisms. This article reviews recent advances in understanding the role of the primary and secondary structures of animal miRNA precursors through the biogenesis stages and the miRNA maturation steps. Also, we describe the effects of genetic variability and heterogeneity of miRNA ends, which play an important role in epitranscriptomics as well as annotation errors in the miRNA databases.

KW - biogenesis

KW - epigenetics

KW - miRNA

KW - mirtron

KW - mutation

KW - pre-miRNA

KW - secondary structure

KW - single nucleotide polymorphism

KW - MICRORNA BIOGENESIS

KW - NUCLEAR EXPORT

KW - DICER

KW - MESSENGER-RNA

KW - NONCODING RNAS

KW - DROSHA

KW - HNRNP A1

KW - PROTEINS

KW - PRE-MICRORNA

KW - BINDING

UR - http://www.scopus.com/inward/record.url?scp=85079497188&partnerID=8YFLogxK

U2 - 10.1134/S1022795420010135

DO - 10.1134/S1022795420010135

M3 - Review article

AN - SCOPUS:85079497188

VL - 56

SP - 17

EP - 29

JO - Russian Journal of Genetics

JF - Russian Journal of Genetics

SN - 1022-7954

IS - 1

ER -