Research output: Contribution to journal › Review article › peer-review
How miRNA Structure of Animals Influences Their Biogenesis. / Vorozheykin, P. S.; Titov, I. I.
In: Russian Journal of Genetics, Vol. 56, No. 1, 01.2020, p. 17-29.Research output: Contribution to journal › Review article › peer-review
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TY - JOUR
T1 - How miRNA Structure of Animals Influences Their Biogenesis
AU - Vorozheykin, P. S.
AU - Titov, I. I.
N1 - Publisher Copyright: © 2020, Pleiades Publishing, Inc.
PY - 2020/1
Y1 - 2020/1
N2 - MicroRNAs are small noncoding RNAs that are involved in the post-transcriptional regulation of the gene expression in various organisms. This article reviews recent advances in understanding the role of the primary and secondary structures of animal miRNA precursors through the biogenesis stages and the miRNA maturation steps. Also, we describe the effects of genetic variability and heterogeneity of miRNA ends, which play an important role in epitranscriptomics as well as annotation errors in the miRNA databases.
AB - MicroRNAs are small noncoding RNAs that are involved in the post-transcriptional regulation of the gene expression in various organisms. This article reviews recent advances in understanding the role of the primary and secondary structures of animal miRNA precursors through the biogenesis stages and the miRNA maturation steps. Also, we describe the effects of genetic variability and heterogeneity of miRNA ends, which play an important role in epitranscriptomics as well as annotation errors in the miRNA databases.
KW - biogenesis
KW - epigenetics
KW - miRNA
KW - mirtron
KW - mutation
KW - pre-miRNA
KW - secondary structure
KW - single nucleotide polymorphism
KW - MICRORNA BIOGENESIS
KW - NUCLEAR EXPORT
KW - DICER
KW - MESSENGER-RNA
KW - NONCODING RNAS
KW - DROSHA
KW - HNRNP A1
KW - PROTEINS
KW - PRE-MICRORNA
KW - BINDING
UR - http://www.scopus.com/inward/record.url?scp=85079497188&partnerID=8YFLogxK
U2 - 10.1134/S1022795420010135
DO - 10.1134/S1022795420010135
M3 - Review article
AN - SCOPUS:85079497188
VL - 56
SP - 17
EP - 29
JO - Russian Journal of Genetics
JF - Russian Journal of Genetics
SN - 1022-7954
IS - 1
ER -
ID: 23524380