Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
High Antimetastatic Activity of Platin Liposomal Form after Lyophilization and Storage. / Kaledin, V. I.; Nikolin, V. P.; Popova, N. A. и др.
в: Bulletin of Experimental Biology and Medicine, Том 163, № 3, 01.07.2017, стр. 349-351.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - High Antimetastatic Activity of Platin Liposomal Form after Lyophilization and Storage
AU - Kaledin, V. I.
AU - Nikolin, V. P.
AU - Popova, N. A.
AU - Klinnikova, M. G.
AU - Bogdanova, L. A.
AU - Morozkova, T. S.
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Antimetastatic activity of Platin in lyophilized liposomes stored for 7 years after fabrication was evaluated. The main flaw of liposomes as vehicles for drug delivery to the tumors is their high affinity for the liver, which accumulates a great amount thereof. This property of liposomes can be used for adjuvant therapy of operable primary tumors metastasizing to the liver. It is shown on the model of mouse GA-1 tumor metastases in the liver that platinum(II) complex compound Platin in phosphatidylcholine-cholesterol liposomes, stored for 7 years after lyophilization, causes complete cure of 40% animals, while free Platin prolongs the lifespan of mice with tumors by only 31.7% vs. control (no treatment).
AB - Antimetastatic activity of Platin in lyophilized liposomes stored for 7 years after fabrication was evaluated. The main flaw of liposomes as vehicles for drug delivery to the tumors is their high affinity for the liver, which accumulates a great amount thereof. This property of liposomes can be used for adjuvant therapy of operable primary tumors metastasizing to the liver. It is shown on the model of mouse GA-1 tumor metastases in the liver that platinum(II) complex compound Platin in phosphatidylcholine-cholesterol liposomes, stored for 7 years after lyophilization, causes complete cure of 40% animals, while free Platin prolongs the lifespan of mice with tumors by only 31.7% vs. control (no treatment).
KW - ascitic tumor
KW - liposomes
KW - metastases
KW - platinum compounds
UR - http://www.scopus.com/inward/record.url?scp=85025842104&partnerID=8YFLogxK
U2 - 10.1007/s10517-017-3801-3
DO - 10.1007/s10517-017-3801-3
M3 - Article
C2 - 28744651
AN - SCOPUS:85025842104
VL - 163
SP - 349
EP - 351
JO - Bulletin of Experimental Biology and Medicine
JF - Bulletin of Experimental Biology and Medicine
SN - 0007-4888
IS - 3
ER -
ID: 9961484