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High Antimetastatic Activity of Platin Liposomal Form after Lyophilization and Storage. / Kaledin, V. I.; Nikolin, V. P.; Popova, N. A. et al.

In: Bulletin of Experimental Biology and Medicine, Vol. 163, No. 3, 01.07.2017, p. 349-351.

Research output: Contribution to journal › Article › peer-review

Harvard

Kaledin, VI, Nikolin, VP, Popova, NA, Klinnikova, MG, Bogdanova, LA & Morozkova, TS 2017, 'High Antimetastatic Activity of Platin Liposomal Form after Lyophilization and Storage', Bulletin of Experimental Biology and Medicine, vol. 163, no. 3, pp. 349-351. https://doi.org/10.1007/s10517-017-3801-3

APA

Kaledin, V. I., Nikolin, V. P., Popova, N. A., Klinnikova, M. G., Bogdanova, L. A., & Morozkova, T. S. (2017). High Antimetastatic Activity of Platin Liposomal Form after Lyophilization and Storage. Bulletin of Experimental Biology and Medicine, 163(3), 349-351. https://doi.org/10.1007/s10517-017-3801-3

Vancouver

Kaledin VI, Nikolin VP, Popova NA, Klinnikova MG, Bogdanova LA, Morozkova TS. High Antimetastatic Activity of Platin Liposomal Form after Lyophilization and Storage. Bulletin of Experimental Biology and Medicine. 2017 Jul 1;163(3):349-351. doi: 10.1007/s10517-017-3801-3

Author

Kaledin, V. I. ; Nikolin, V. P. ; Popova, N. A. et al. / High Antimetastatic Activity of Platin Liposomal Form after Lyophilization and Storage. In: Bulletin of Experimental Biology and Medicine. 2017 ; Vol. 163, No. 3. pp. 349-351.

BibTeX

@article{3bbc5fdd761a4545b5496d1e1a9c5101,
title = "High Antimetastatic Activity of Platin Liposomal Form after Lyophilization and Storage",
abstract = "Antimetastatic activity of Platin in lyophilized liposomes stored for 7 years after fabrication was evaluated. The main flaw of liposomes as vehicles for drug delivery to the tumors is their high affinity for the liver, which accumulates a great amount thereof. This property of liposomes can be used for adjuvant therapy of operable primary tumors metastasizing to the liver. It is shown on the model of mouse GA-1 tumor metastases in the liver that platinum(II) complex compound Platin in phosphatidylcholine-cholesterol liposomes, stored for 7 years after lyophilization, causes complete cure of 40% animals, while free Platin prolongs the lifespan of mice with tumors by only 31.7% vs. control (no treatment).",
keywords = "ascitic tumor, liposomes, metastases, platinum compounds",
author = "Kaledin, {V. I.} and Nikolin, {V. P.} and Popova, {N. A.} and Klinnikova, {M. G.} and Bogdanova, {L. A.} and Morozkova, {T. S.}",
year = "2017",
month = jul,
day = "1",
doi = "10.1007/s10517-017-3801-3",
language = "English",
volume = "163",
pages = "349--351",
journal = "Bulletin of Experimental Biology and Medicine",
issn = "0007-4888",
publisher = "Springer New York",
number = "3",

}

RIS

TY - JOUR

T1 - High Antimetastatic Activity of Platin Liposomal Form after Lyophilization and Storage

AU - Kaledin, V. I.

AU - Nikolin, V. P.

AU - Popova, N. A.

AU - Klinnikova, M. G.

AU - Bogdanova, L. A.

AU - Morozkova, T. S.

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Antimetastatic activity of Platin in lyophilized liposomes stored for 7 years after fabrication was evaluated. The main flaw of liposomes as vehicles for drug delivery to the tumors is their high affinity for the liver, which accumulates a great amount thereof. This property of liposomes can be used for adjuvant therapy of operable primary tumors metastasizing to the liver. It is shown on the model of mouse GA-1 tumor metastases in the liver that platinum(II) complex compound Platin in phosphatidylcholine-cholesterol liposomes, stored for 7 years after lyophilization, causes complete cure of 40% animals, while free Platin prolongs the lifespan of mice with tumors by only 31.7% vs. control (no treatment).

AB - Antimetastatic activity of Platin in lyophilized liposomes stored for 7 years after fabrication was evaluated. The main flaw of liposomes as vehicles for drug delivery to the tumors is their high affinity for the liver, which accumulates a great amount thereof. This property of liposomes can be used for adjuvant therapy of operable primary tumors metastasizing to the liver. It is shown on the model of mouse GA-1 tumor metastases in the liver that platinum(II) complex compound Platin in phosphatidylcholine-cholesterol liposomes, stored for 7 years after lyophilization, causes complete cure of 40% animals, while free Platin prolongs the lifespan of mice with tumors by only 31.7% vs. control (no treatment).

KW - ascitic tumor

KW - liposomes

KW - metastases

KW - platinum compounds

UR - http://www.scopus.com/inward/record.url?scp=85025842104&partnerID=8YFLogxK

U2 - 10.1007/s10517-017-3801-3

DO - 10.1007/s10517-017-3801-3

M3 - Article

C2 - 28744651

AN - SCOPUS:85025842104

VL - 163

SP - 349

EP - 351

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 3

ER -

ID: 9961484