Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Heterogeneous Microtesla SABRE Enhancement of 15N NMR Signals. / Kovtunov, Kirill V.; Kovtunova, Larisa M.; Gemeinhardt, Max E. и др.
в: Angewandte Chemie - International Edition, Том 56, № 35, 21.08.2017, стр. 10433-10437.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Heterogeneous Microtesla SABRE Enhancement of 15N NMR Signals
AU - Kovtunov, Kirill V.
AU - Kovtunova, Larisa M.
AU - Gemeinhardt, Max E.
AU - Bukhtiyarov, Andrey V.
AU - Gesiorski, Jonathan
AU - Bukhtiyarov, Valerii I.
AU - Chekmenev, Eduard Y.
AU - Koptyug, Igor V.
AU - Goodson, Boyd M.
N1 - Publisher Copyright: © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2017/8/21
Y1 - 2017/8/21
N2 - The hyperpolarization of heteronuclei via signal amplification by reversible exchange (SABRE) was investigated under conditions of heterogeneous catalysis and microtesla magnetic fields. Immobilization of [IrCl(COD)(IMes)], [IMes=1,3-bis(2,4,6-trimethylphenyl), imidazole-2-ylidene; COD=cyclooctadiene] catalyst onto silica particles modified with amine linkers engenders an effective heterogeneous SABRE (HET-SABRE) catalyst that was used to demonstrate a circa 100-fold enhancement of 15N NMR signals in 15N-pyridine at 9.4 T following parahydrogen bubbling within a magnetic shield. No 15N NMR enhancement was observed from the supernatant liquid following catalyst separation, which along with XPS characterization supports the fact that the effects result from SABRE under heterogeneous catalytic conditions. The technique can be developed further for producing catalyst-free agents via SABRE with hyperpolarized heteronuclear spins, and thus is promising for biomedical NMR and MRI applications.
AB - The hyperpolarization of heteronuclei via signal amplification by reversible exchange (SABRE) was investigated under conditions of heterogeneous catalysis and microtesla magnetic fields. Immobilization of [IrCl(COD)(IMes)], [IMes=1,3-bis(2,4,6-trimethylphenyl), imidazole-2-ylidene; COD=cyclooctadiene] catalyst onto silica particles modified with amine linkers engenders an effective heterogeneous SABRE (HET-SABRE) catalyst that was used to demonstrate a circa 100-fold enhancement of 15N NMR signals in 15N-pyridine at 9.4 T following parahydrogen bubbling within a magnetic shield. No 15N NMR enhancement was observed from the supernatant liquid following catalyst separation, which along with XPS characterization supports the fact that the effects result from SABRE under heterogeneous catalytic conditions. The technique can be developed further for producing catalyst-free agents via SABRE with hyperpolarized heteronuclear spins, and thus is promising for biomedical NMR and MRI applications.
KW - het-SABRE
KW - heterogeneous catalysis
KW - heteronuclei
KW - hyperpolarization
KW - parahydrogen
KW - Magnetic Resonance Spectroscopy
KW - Organometallic Compounds/chemistry
KW - Catalysis
KW - Hydrogen/chemistry
KW - Nitrogen Isotopes
KW - REVERSIBLE EXCHANGE SABRE
KW - CATALYST
KW - HYDROGEN-INDUCED POLARIZATION
KW - HIGH MAGNETIC-FIELD
KW - NUCLEAR-SPIN HYPERPOLARIZATION
KW - AMPLIFICATION
KW - RESONANCE
KW - PARAHYDROGEN-INDUCED POLARIZATION
KW - IN-SITU
KW - STATE NMR
UR - http://www.scopus.com/inward/record.url?scp=85026362064&partnerID=8YFLogxK
U2 - 10.1002/anie.201705014
DO - 10.1002/anie.201705014
M3 - Article
C2 - 28644918
AN - SCOPUS:85026362064
VL - 56
SP - 10433
EP - 10437
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
SN - 1433-7851
IS - 35
ER -
ID: 9055683