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Heterogeneous Microtesla SABRE Enhancement of 15N NMR Signals. / Kovtunov, Kirill V.; Kovtunova, Larisa M.; Gemeinhardt, Max E. et al.

In: Angewandte Chemie - International Edition, Vol. 56, No. 35, 21.08.2017, p. 10433-10437.

Research output: Contribution to journal › Article › peer-review

Harvard

Kovtunov, KV, Kovtunova, LM, Gemeinhardt, ME, Bukhtiyarov, AV, Gesiorski, J, Bukhtiyarov, VI, Chekmenev, EY, Koptyug, IV & Goodson, BM 2017, 'Heterogeneous Microtesla SABRE Enhancement of 15N NMR Signals', Angewandte Chemie - International Edition, vol. 56, no. 35, pp. 10433-10437. https://doi.org/10.1002/anie.201705014

APA

Kovtunov, K. V., Kovtunova, L. M., Gemeinhardt, M. E., Bukhtiyarov, A. V., Gesiorski, J., Bukhtiyarov, V. I., Chekmenev, E. Y., Koptyug, I. V., & Goodson, B. M. (2017). Heterogeneous Microtesla SABRE Enhancement of 15N NMR Signals. Angewandte Chemie - International Edition, 56(35), 10433-10437. https://doi.org/10.1002/anie.201705014

Vancouver

Kovtunov KV, Kovtunova LM, Gemeinhardt ME, Bukhtiyarov AV, Gesiorski J, Bukhtiyarov VI et al. Heterogeneous Microtesla SABRE Enhancement of 15N NMR Signals. Angewandte Chemie - International Edition. 2017 Aug 21;56(35):10433-10437. doi: 10.1002/anie.201705014

Author

Kovtunov, Kirill V. ; Kovtunova, Larisa M. ; Gemeinhardt, Max E. et al. / Heterogeneous Microtesla SABRE Enhancement of 15N NMR Signals. In: Angewandte Chemie - International Edition. 2017 ; Vol. 56, No. 35. pp. 10433-10437.

BibTeX

@article{b20362127891475aafec89db802c9291,
title = "Heterogeneous Microtesla SABRE Enhancement of 15N NMR Signals",
abstract = "The hyperpolarization of heteronuclei via signal amplification by reversible exchange (SABRE) was investigated under conditions of heterogeneous catalysis and microtesla magnetic fields. Immobilization of [IrCl(COD)(IMes)], [IMes=1,3-bis(2,4,6-trimethylphenyl), imidazole-2-ylidene; COD=cyclooctadiene] catalyst onto silica particles modified with amine linkers engenders an effective heterogeneous SABRE (HET-SABRE) catalyst that was used to demonstrate a circa 100-fold enhancement of 15N NMR signals in 15N-pyridine at 9.4 T following parahydrogen bubbling within a magnetic shield. No 15N NMR enhancement was observed from the supernatant liquid following catalyst separation, which along with XPS characterization supports the fact that the effects result from SABRE under heterogeneous catalytic conditions. The technique can be developed further for producing catalyst-free agents via SABRE with hyperpolarized heteronuclear spins, and thus is promising for biomedical NMR and MRI applications.",
keywords = "het-SABRE, heterogeneous catalysis, heteronuclei, hyperpolarization, parahydrogen, Magnetic Resonance Spectroscopy, Organometallic Compounds/chemistry, Catalysis, Hydrogen/chemistry, Nitrogen Isotopes, REVERSIBLE EXCHANGE SABRE, CATALYST, HYDROGEN-INDUCED POLARIZATION, HIGH MAGNETIC-FIELD, NUCLEAR-SPIN HYPERPOLARIZATION, AMPLIFICATION, RESONANCE, PARAHYDROGEN-INDUCED POLARIZATION, IN-SITU, STATE NMR",
author = "Kovtunov, {Kirill V.} and Kovtunova, {Larisa M.} and Gemeinhardt, {Max E.} and Bukhtiyarov, {Andrey V.} and Jonathan Gesiorski and Bukhtiyarov, {Valerii I.} and Chekmenev, {Eduard Y.} and Koptyug, {Igor V.} and Goodson, {Boyd M.}",
note = "Publisher Copyright: {\textcopyright} 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2017",
month = aug,
day = "21",
doi = "10.1002/anie.201705014",
language = "English",
volume = "56",
pages = "10433--10437",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "35",

}

RIS

TY - JOUR

T1 - Heterogeneous Microtesla SABRE Enhancement of 15N NMR Signals

AU - Kovtunov, Kirill V.

AU - Kovtunova, Larisa M.

AU - Gemeinhardt, Max E.

AU - Bukhtiyarov, Andrey V.

AU - Gesiorski, Jonathan

AU - Bukhtiyarov, Valerii I.

AU - Chekmenev, Eduard Y.

AU - Koptyug, Igor V.

AU - Goodson, Boyd M.

N1 - Publisher Copyright: © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

PY - 2017/8/21

Y1 - 2017/8/21

N2 - The hyperpolarization of heteronuclei via signal amplification by reversible exchange (SABRE) was investigated under conditions of heterogeneous catalysis and microtesla magnetic fields. Immobilization of [IrCl(COD)(IMes)], [IMes=1,3-bis(2,4,6-trimethylphenyl), imidazole-2-ylidene; COD=cyclooctadiene] catalyst onto silica particles modified with amine linkers engenders an effective heterogeneous SABRE (HET-SABRE) catalyst that was used to demonstrate a circa 100-fold enhancement of 15N NMR signals in 15N-pyridine at 9.4 T following parahydrogen bubbling within a magnetic shield. No 15N NMR enhancement was observed from the supernatant liquid following catalyst separation, which along with XPS characterization supports the fact that the effects result from SABRE under heterogeneous catalytic conditions. The technique can be developed further for producing catalyst-free agents via SABRE with hyperpolarized heteronuclear spins, and thus is promising for biomedical NMR and MRI applications.

AB - The hyperpolarization of heteronuclei via signal amplification by reversible exchange (SABRE) was investigated under conditions of heterogeneous catalysis and microtesla magnetic fields. Immobilization of [IrCl(COD)(IMes)], [IMes=1,3-bis(2,4,6-trimethylphenyl), imidazole-2-ylidene; COD=cyclooctadiene] catalyst onto silica particles modified with amine linkers engenders an effective heterogeneous SABRE (HET-SABRE) catalyst that was used to demonstrate a circa 100-fold enhancement of 15N NMR signals in 15N-pyridine at 9.4 T following parahydrogen bubbling within a magnetic shield. No 15N NMR enhancement was observed from the supernatant liquid following catalyst separation, which along with XPS characterization supports the fact that the effects result from SABRE under heterogeneous catalytic conditions. The technique can be developed further for producing catalyst-free agents via SABRE with hyperpolarized heteronuclear spins, and thus is promising for biomedical NMR and MRI applications.

KW - het-SABRE

KW - heterogeneous catalysis

KW - heteronuclei

KW - hyperpolarization

KW - parahydrogen

KW - Magnetic Resonance Spectroscopy

KW - Organometallic Compounds/chemistry

KW - Catalysis

KW - Hydrogen/chemistry

KW - Nitrogen Isotopes

KW - REVERSIBLE EXCHANGE SABRE

KW - CATALYST

KW - HYDROGEN-INDUCED POLARIZATION

KW - HIGH MAGNETIC-FIELD

KW - NUCLEAR-SPIN HYPERPOLARIZATION

KW - AMPLIFICATION

KW - RESONANCE

KW - PARAHYDROGEN-INDUCED POLARIZATION

KW - IN-SITU

KW - STATE NMR

UR - http://www.scopus.com/inward/record.url?scp=85026362064&partnerID=8YFLogxK

U2 - 10.1002/anie.201705014

DO - 10.1002/anie.201705014

M3 - Article

C2 - 28644918

AN - SCOPUS:85026362064

VL - 56

SP - 10433

EP - 10437

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 35

ER -

ID: 9055683