TY - JOUR

T1 - Hepatitis C virus subtype 3a was introduced in the USSR in the early 1980s

AU - Manuylov, Victor A.

AU - Chub, Elena V.

AU - Kichatova, Vera S.

AU - Soboleva, Natalya V.

AU - Isaeva, Olga V.

AU - Zamyatnin, Andrey A.

AU - Netesov, Sergey V.

PY - 2017/8/1

Y1 - 2017/8/1

N2 - A total of 2120 nucleotide sequences of the NS5b region of HCV subtype 3a were analysed, including 310 strains derived from former republics of the USSR (Azerbaijan, Estonia, Lithuania, Russia, Tajikistan and Uzbekistan). Among the viral isolates collected from former regions of the Soviet Union, 294 strains formed 3 sustained phylogenetic clusters, with each having a common origin. Phylodynamic analysis demonstrated that the most recent common ancestors of the current strains inside the three clusters were introduced into the USSR population in 1981±1, 1984±2 and 1985±2, respectively (the confidence intervals were calculated using Student’s t-distribution, P<0.05). The time estimation obtained for HCV subtype 3a correlated well with the historical and epidemiological context of this period, and in particular with the start of widespread injection drug use in the USSR in the first half of the 1980s.

AB - A total of 2120 nucleotide sequences of the NS5b region of HCV subtype 3a were analysed, including 310 strains derived from former republics of the USSR (Azerbaijan, Estonia, Lithuania, Russia, Tajikistan and Uzbekistan). Among the viral isolates collected from former regions of the Soviet Union, 294 strains formed 3 sustained phylogenetic clusters, with each having a common origin. Phylodynamic analysis demonstrated that the most recent common ancestors of the current strains inside the three clusters were introduced into the USSR population in 1981±1, 1984±2 and 1985±2, respectively (the confidence intervals were calculated using Student’s t-distribution, P<0.05). The time estimation obtained for HCV subtype 3a correlated well with the historical and epidemiological context of this period, and in particular with the start of widespread injection drug use in the USSR in the first half of the 1980s.

KW - Former USSR

KW - Hepatitis C virus

KW - Subtype 3a

UR - http://www.scopus.com/inward/record.url?scp=85028803800&partnerID=8YFLogxK

U2 - 10.1099/jgv.0.000878

DO - 10.1099/jgv.0.000878

M3 - Article

C2 - 28742003

AN - SCOPUS:85028803800

VL - 98

SP - 2079

EP - 2087

JO - Journal of General Virology

JF - Journal of General Virology

SN - 0022-1317

IS - 8

M1 - 000878

ER -