Research output: Contribution to journal › Article › peer-review
Hepatitis C virus subtype 3a was introduced in the USSR in the early 1980s. / Manuylov, Victor A.; Chub, Elena V.; Kichatova, Vera S. et al.
In: Journal of General Virology, Vol. 98, No. 8, 000878, 01.08.2017, p. 2079-2087.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Hepatitis C virus subtype 3a was introduced in the USSR in the early 1980s
AU - Manuylov, Victor A.
AU - Chub, Elena V.
AU - Kichatova, Vera S.
AU - Soboleva, Natalya V.
AU - Isaeva, Olga V.
AU - Zamyatnin, Andrey A.
AU - Netesov, Sergey V.
PY - 2017/8/1
Y1 - 2017/8/1
N2 - A total of 2120 nucleotide sequences of the NS5b region of HCV subtype 3a were analysed, including 310 strains derived from former republics of the USSR (Azerbaijan, Estonia, Lithuania, Russia, Tajikistan and Uzbekistan). Among the viral isolates collected from former regions of the Soviet Union, 294 strains formed 3 sustained phylogenetic clusters, with each having a common origin. Phylodynamic analysis demonstrated that the most recent common ancestors of the current strains inside the three clusters were introduced into the USSR population in 1981±1, 1984±2 and 1985±2, respectively (the confidence intervals were calculated using Student’s t-distribution, P<0.05). The time estimation obtained for HCV subtype 3a correlated well with the historical and epidemiological context of this period, and in particular with the start of widespread injection drug use in the USSR in the first half of the 1980s.
AB - A total of 2120 nucleotide sequences of the NS5b region of HCV subtype 3a were analysed, including 310 strains derived from former republics of the USSR (Azerbaijan, Estonia, Lithuania, Russia, Tajikistan and Uzbekistan). Among the viral isolates collected from former regions of the Soviet Union, 294 strains formed 3 sustained phylogenetic clusters, with each having a common origin. Phylodynamic analysis demonstrated that the most recent common ancestors of the current strains inside the three clusters were introduced into the USSR population in 1981±1, 1984±2 and 1985±2, respectively (the confidence intervals were calculated using Student’s t-distribution, P<0.05). The time estimation obtained for HCV subtype 3a correlated well with the historical and epidemiological context of this period, and in particular with the start of widespread injection drug use in the USSR in the first half of the 1980s.
KW - Former USSR
KW - Hepatitis C virus
KW - Subtype 3a
UR - http://www.scopus.com/inward/record.url?scp=85028803800&partnerID=8YFLogxK
U2 - 10.1099/jgv.0.000878
DO - 10.1099/jgv.0.000878
M3 - Article
C2 - 28742003
AN - SCOPUS:85028803800
VL - 98
SP - 2079
EP - 2087
JO - Journal of General Virology
JF - Journal of General Virology
SN - 0022-1317
IS - 8
M1 - 000878
ER -
ID: 8690395